Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/16153
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kapnisis, Konstantinos | - |
dc.contributor.author | Seidner, H | - |
dc.contributor.author | Prokopi, Marianna | - |
dc.contributor.author | Pasias, Dimitris | - |
dc.contributor.author | Pitsillides, Costas | - |
dc.contributor.author | Anayiotos, Andreas | - |
dc.contributor.author | Kaliviotis, Efstathios | - |
dc.date.accessioned | 2020-02-18T10:37:31Z | - |
dc.date.available | 2020-02-18T10:37:31Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Clinical Hemorheology and Microcirculation, 2019, vol. 72, no. 4, pp. 375-393 | en_US |
dc.identifier.issn | 13860291 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/16153 | - |
dc.description.abstract | Despite their wide clinical usage, stent functionality may be compromised by complications at the site of implantation, including early/late stent thrombosis and occlusion. Although several studies have described the effect of fluid-structure interaction on local haemodynamics, there is yet limited information on the effect of the stent presence on specific hemorheological parameters. The current work investigates the red blood cell (RBC) mechanical behavior and physiological changes as a result of flow through stented vessels. Blood samples from healthy volunteers were prepared as RBC suspensions in plasma and in phosphate buffer saline at 45% haematocrit. Self-expanding nitinol stents were inserted in clear perfluoroalkoxy alkane tubing which was connected to a syringe, and integrated in a syringe pump. The samples were tested at flow rates of 17.5, 35 and 70 ml/min, and control tests were performed in non-stented vessels. For each flow rate, the sample viscosity, RBC aggregation and deformability, and RBC lysis were estimated. The results indicate that the presence of a stent in a vessel has an influence on the hemorheological characteristics of blood. The viscosity of all samples increases slightly with the increase of the flow rate and exposure. RBC aggregation and elongation index (EI) decrease as the flow rate and exposure increases. RBC lysis for the extreme cases is evident. The results indicate that the stresses developed in the stent area for the extreme conditions could be sufficiently high to influence the integrity of the RBC membrane. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Clinical hemorheology and microcirculation | en_US |
dc.rights | © IOS | en_US |
dc.subject | Blood viscosity | en_US |
dc.subject | Cardiovascular stent | en_US |
dc.subject | Lysis | en_US |
dc.subject | Red blood cell aggregation | en_US |
dc.subject | Red blood cell deformability | en_US |
dc.title | The effects of stenting on hemorheological parameters: An in vitro investigation under various blood flow conditions | en_US |
dc.type | Article | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | University College London | en_US |
dc.subject.category | Mechanical Engineering | en_US |
dc.journals | Subscription | en_US |
dc.country | Cyprus | en_US |
dc.country | United Kingdom | en_US |
dc.subject.field | Engineering and Technology | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.3233/CH-180540 | en_US |
dc.identifier.pmid | 31006672 | - |
dc.identifier.scopus | 2-s2.0-85073081317 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85073081317 | - |
dc.relation.issue | 4 | en_US |
dc.relation.volume | 72 | en_US |
cut.common.academicyear | 2018-2019 | en_US |
dc.identifier.spage | 375 | en_US |
dc.identifier.epage | 393 | en_US |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Department of Mechanical Engineering and Materials Science and Engineering | - |
crisitem.author.dept | Department of Mechanical Engineering and Materials Science and Engineering | - |
crisitem.author.dept | Department of Mechanical Engineering and Materials Science and Engineering | - |
crisitem.author.dept | Department of Mechanical Engineering and Materials Science and Engineering | - |
crisitem.author.dept | Department of Mechanical Engineering and Materials Science and Engineering | - |
crisitem.author.faculty | Faculty of Engineering and Technology | - |
crisitem.author.faculty | Faculty of Engineering and Technology | - |
crisitem.author.faculty | Faculty of Engineering and Technology | - |
crisitem.author.faculty | Faculty of Engineering and Technology | - |
crisitem.author.faculty | Faculty of Engineering and Technology | - |
crisitem.author.orcid | 0000-0002-4999-0231 | - |
crisitem.author.orcid | 0000-0003-4123-3065 | - |
crisitem.author.orcid | 0000-0003-4471-7604 | - |
crisitem.author.orcid | 0000-0003-4149-4396 | - |
crisitem.author.parentorg | Faculty of Engineering and Technology | - |
crisitem.author.parentorg | Faculty of Engineering and Technology | - |
crisitem.author.parentorg | Faculty of Engineering and Technology | - |
crisitem.author.parentorg | Faculty of Engineering and Technology | - |
crisitem.author.parentorg | Faculty of Engineering and Technology | - |
crisitem.journal.journalissn | 1875-8622 | - |
crisitem.journal.publisher | IOS Press | - |
Appears in Collections: | Άρθρα/Articles |
CORE Recommender
Items in KTISIS are protected by copyright, with all rights reserved, unless otherwise indicated.