Παρακαλώ χρησιμοποιήστε αυτό το αναγνωριστικό για να παραπέμψετε ή να δημιουργήσετε σύνδεσμο προς αυτό το τεκμήριο:
https://hdl.handle.net/20.500.14279/1064
Τίτλος: | In vitro synergism of β-lactams with ciprofloxacin and moxifloxacin against genetically distinct multidrug-resistant isolates of Pseudomonas aeruginosa | Συγγραφείς: | Kanellakopoulou, Kyriaki Galani, Irene Giamarellou, Helen J. Giamarellos-Bourboulis, Evangelos J. Sarafis, Pavlos |
Major Field of Science: | Medical and Health Sciences | Field Category: | Basic Medicine | Λέξεις-κλειδιά: | Ceftazidime;Carbapenems;Ciprofloxacin;Moxifloxacin;Pseudomonas aeruginosa;Resistance | Ημερομηνία Έκδοσης: | Ιου-2008 | Πηγή: | International Journal of Antimicrobial Agents, 2008, vol. 32, iss. 1, pp. 33–39 | Volume: | 32 | Issue: | 1 | Start page: | 33 | End page: | 39 | Περιοδικό: | International Journal of Antimicrobial Agents | Περίληψη: | In vitro combinations of β-lactams with fluoroquinolones against multidrug-resistant (MDR) Pseudomonas aeruginosa were tested. From a total of 200 isolates, 24 genetically distinct isolates defined by pulsed-field gel electrophoresis (PFGE) were selected. The isolates were exposed over time to imipenem, meropenem and ceftazidime as well as to their combinations with ciprofloxacin and moxifloxacin. All isolates were resistant to all agents tested at concentrations equal to their average serum level. Synergy of any of the tested combinations was found in 10 isolates (41.7%). This was shown after 4 h and 6 h of exposure accompanied by re-growth after 24 h. Not all the tested combinations were active against the same isolates. The combinations of imipenem + ciprofloxacin, ceftazidime + ciprofloxacin and imipenem + moxifloxacin were the most active. When time–kill assays were repeated for the latter isolates at antimicrobial concentrations equal to their maximum serum levels, synergy was prolonged to 24 h. The present findings should be interpreted with caution for the management of infections by MDR P. aeruginosa. They underscore the potential interest of reporting synergism between β-lactams and fluoroquinolones in the nosocomial setting when a MDR isolate emerges. | URI: | https://hdl.handle.net/20.500.14279/1064 | ISSN: | 18727913 | DOI: | 10.1016/j.ijantimicag.2008.02.019 | Rights: | © Elsevier | Type: | Article | Affiliation: | National and Kapodistrian University of Athens | Publication Type: | Peer Reviewed |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
CORE Recommender
SCOPUSTM
Citations
16
checked on 9 Νοε 2023
WEB OF SCIENCETM
Citations
20
12
Last Week
0
0
Last month
0
0
checked on 29 Οκτ 2023
Page view(s)
566
Last Week
2
2
Last month
31
31
checked on 13 Μαρ 2025
Google ScholarTM
Check
Altmetric
Όλα τα τεκμήρια του δικτυακού τόπου προστατεύονται από πνευματικά δικαιώματα