Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/9865
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dc.contributor.authorSavva, Savvas C.-
dc.contributor.authorLamnisos, Demetris-
dc.contributor.authorKafatos, Anthony George-
dc.date.accessioned2017-02-23T12:27:24Z-
dc.date.available2017-02-23T12:27:24Z-
dc.date.issued2013-10-24-
dc.identifier.citationDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2013, vol. 6, pp. 403-419en_US
dc.identifier.issn11787007-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/9865-
dc.description.abstractBackground and objectives: The identification of increased cardiometabolic risk among asymptomatic individuals remains a huge challenge. The aim of this meta-analysis was to compare the association of body mass index (BMI), which is an index of general obesity, and waist-to-height ratio (WHtR), an index of abdominal obesity, with cardiometabolic risk in cross-sectional and prospective studies. Methods: PubMed and Embase databases were searched for cross-sectional or prospective studies that evaluated the association of both BMI and WHtR with several cardiometabolic outcomes. The strength of relative risk (RR) with 95% confdence interval (CI) was calculated using the optimal cutoffs of BMI and WHtR in cross-sectional studies, while any available cutoff was used in prospective studies. The pooled estimate of the ratio of RRs (rRR [=RRBMI/ RRWHtR]) with 95% CIs was used to compare the association of WHtR and BMI with car-diometabolic risk. Meta-regression was used to identify possible sources of heterogeneity between the studies. Results: Twenty-four cross-sectional studies and ten prospective studies with a total number of 512,809 participants were identifed as suitable for the purpose of this meta-analysis. WHtR was found to have a stronger association than BMI with diabetes mellitus (rRR: 0.71, 95% CI: 0.59-0.84) and metabolic syndrome (rRR: 0.92, 95% CI: 0.89-0.96) in cross-sectional studies. Also in prospective studies, WHtR appears to be superior to BMI in detecting several outcomes, including incident cardiovascular disease, cardiovascular disease mortality, and all-cause mortality. The usefulness of WHtR appears to be better in Asian than in non-Asian populations. BMI was not superior to WHtR in any of the outcomes that were evaluated. However, the results of the utilized approach should be interpreted cautiously because of a substantial heterogeneity between the results of the studies. Meta-regression analysis was performed to explain this heterogeneity, but none of the evaluated factors, ie, sex, origin (Asians, non-Asians), and optimal BMI or WHtR cutoffs were signifcantly related with rRR. Conclusion: The results of this meta-analysis support the use of WHtR in identifying adults at increased cardiometabolic risk. However, further evidence is warranted because of a substantial heterogeneity between the studies.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofDiabetes, Metabolic Syndrome and Obesityen_US
dc.rights© Savva et al.en_US
dc.subjectBody mass indexen_US
dc.subjectCardiometabolicen_US
dc.subjectMeta-analysisen_US
dc.subjectWaist-to-height ratioen_US
dc.titlePredicting cardiometabolic risk: Waist-to-height ratio or BMI. A meta-analysisen_US
dc.typeArticleen_US
dc.collaborationCyprus Dietetic and Nutrition Associationen_US
dc.collaborationEuropean University Cyprusen_US
dc.collaborationUniversity of Crete School of Medicineen_US
dc.subject.categoryHealth Sciencesen_US
dc.journalsSubscriptionen_US
dc.countryCyprusen_US
dc.countryGreeceen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.2147/DMSO.S34220en_US
dc.identifier.pmid24179379-
dc.relation.volume6en_US
cut.common.academicyear2013-2014en_US
dc.identifier.spage403en_US
dc.identifier.epage419en_US
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.author.deptDepartment of Nursing-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
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