Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/9560
DC FieldValueLanguage
dc.contributor.authorKapnisis, Konstantinos-
dc.contributor.authorConstantinides, Georgios-
dc.contributor.authorGeorgiou, Harry-
dc.contributor.authorCristea, Daniel-
dc.contributor.authorGabor, Camelia-
dc.contributor.authorMunteanu, Daniel-
dc.contributor.authorBrott, Brigitta C.-
dc.contributor.authorAnderson, Peter G.-
dc.contributor.authorLemons, Jack E.-
dc.contributor.authorAnayiotos, Andreas-
dc.contributor.otherΚαπνίσης, Κωνσταντίνος-
dc.contributor.otherΚωνσταντινίδης, Γιώργος-
dc.contributor.otherΓεωργίου, Χάρης-
dc.contributor.otherΑναγιωτός, Ανδρέας-
dc.date.accessioned2017-02-09T10:56:23Z-
dc.date.available2017-02-09T10:56:23Z-
dc.date.issued2014-12-01-
dc.identifier.citationJournal of the Mechanical Behavior of Biomedical Materials, 2014, vol. 40, pp. 240-251en_US
dc.identifier.issn17516161-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/9560-
dc.description.abstractIn-stent restenosis (ISR) remains a significant limitation despite the considerable previous clinical and investigative emphasis on the problem. Complications arising from the interaction of stent materials with the surrounding vessel wall as well as from the mechanical forces developing after implantation, play an important role in the development of ISR. To investigate the relation between mechanical factors and stent structural integrity, and to identify any structural weakness points on the geometry of commercially available Stainless Steel and Cobalt-Chromium stents, accelerated pulsatile durability tests were carried out in a simulated physiological environment. Potential spatial variations in the mechanical properties on stent struts and their role in the observed premature failures of the stent devices during operation were also examined. Fretting wear and fatigue-induced fractures were found on stent surfaces after exposure to cyclic loading similar to that arising in vivo. Nanoindentation studies performed on various locations along the stent struts have shown that the hardness of specific stent locations significantly increases after mechanical expansion. The increase in hardness was associated with a reduction of the material's ability to dissipate energy in plastic deformations, therefore an increased vulnerability to fracture and fatigue. We conclude that the locations of fatigue fractures in stent struts are controlled not only by the geometrically-driven stress concentrations developing during cyclic loading but also by the local material mechanical changes that are imparted on various parts of the stent during the deployment process.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of the Mechanical Behavior of Biomedical Materialsen_US
dc.rights© Elsevieren_US
dc.subjectFractureen_US
dc.subjectIn-stent restenosis (ISR)en_US
dc.subjectMechanical propertiesen_US
dc.subjectNanoindentationen_US
dc.subjectStentsen_US
dc.titleMulti-scale mechanical investigation of stainless steel and cobalt-chromium stentsen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationTransilvania University of Brasoven_US
dc.collaborationUniversity of Alabama at Birminghamen_US
dc.subject.categoryMaterials Engineeringen_US
dc.journalsSubscriptionen_US
dc.countryCyprusen_US
dc.countryRomaniaen_US
dc.countryUnited Statesen_US
dc.subject.fieldEngineering and Technologyen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1016/j.jmbbm.2014.09.010en_US
dc.relation.volume40en_US
cut.common.academicyear2014-2015en_US
dc.identifier.spage240en_US
dc.identifier.epage251en_US
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.orcid0000-0002-4999-0231-
crisitem.author.orcid0000-0003-1979-5176-
crisitem.author.orcid0000-0003-4471-7604-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
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