Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/3818
Title: | Infection probability score : a predictor of clostridium difficile-associated disease onset in patients with haematological malignancy |
Authors: | Apostolopoulou, Eleni A. Terzis, Konstantinos Elefsiniotis, Ioannis S. Raftopoulos, Vasilios |
Major Field of Science: | Medical and Health Sciences |
Field Category: | Clinical Medicine |
Keywords: | APACHE II;Clostridium difficile-associated disease;Healthcare-associated infections;Hematology;Infection probability score;KARNOFSKY |
Issue Date: | Dec-2011 |
Source: | European Journal of Oncology Nursing, 2011, vol. 15, no. 5, pp. 404-409 |
Volume: | 15 |
Issue: | 5 |
Start page: | 404 |
End page: | 409 |
Journal: | European Journal of Oncology Nursing |
Abstract: | Purpose: to assess the predictive power of three systems: Infection Probability Score, APACHE II and KARNOFSKY score for the onset of Clostridium difficile-associated disease (CDAD) in hematology-oncology patients. Methods and sample: A retrospective pilot surveillance survey was conducted in the hematology unit of a general hospital in Greece. Data were collected by using an anonymous standardised case-record form. The sample consisted of 102 hospitalized patients. Results: The majority of the patients (33.3%) suffered from acute myeloid leukemia. The cumulative incidence of CDAD was 10.8% and the incidence rate of C difficile associated diarrhea was 5 per 1000 patient-days (14.2 per 1000 patient-days at risk). Patients with CDAD had twofold higher time of mean length of hospital stay compared with patients without CDAD (38.82 ± 23.88 vs 19.45 ± 14.56 days). Additionally patients with CDAD had received a greater number of different antibiotics compared to those without CDAD (5.18 ± 1.99 vs 2.54 ± 2.13), suffered from diabetes, from non Hodgkin's lymphoma, had a statistically significant higher duration of neutropenia ≥3 days and had received antifungal treatment. The best cutoff value of IPS for the prediction of CDAD was 13 with a sensitivity of 45.5% and a specificity of 82.4%. Conclusions: IPS is an early diagnostic test for CDAD detection. |
URI: | https://hdl.handle.net/20.500.14279/3818 |
ISSN: | 15322122 |
DOI: | 10.1016/j.ejon.2010.11.002 |
Rights: | © Elsevier |
Type: | Article |
Affiliation : | Cyprus University of Technology National and Kapodistrian University of Athens Halkida General Hospital |
Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
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