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https://hdl.handle.net/20.500.14279/3677
Πεδίο DC | Τιμή | Γλώσσα |
---|---|---|
dc.contributor.author | Holmes, Michael Vaclav | - |
dc.contributor.author | Simon, Tabassome | - |
dc.contributor.author | Exeter, Holly J. | - |
dc.contributor.author | Folkersen, Lasse | - |
dc.contributor.author | Asselbergs, Folkert W. | - |
dc.contributor.author | Guardiola, Montse | - |
dc.contributor.author | Cooper, Jackie A. | - |
dc.contributor.author | Palmen, Jutta A. | - |
dc.contributor.author | Hubacek, Jaroslav Alois | - |
dc.contributor.author | Carruthers, Kathryn F. | - |
dc.contributor.author | Horne, Benjamin D. | - |
dc.contributor.author | Adamkova, Vera | - |
dc.contributor.author | Baldassarre, Damiano | - |
dc.contributor.author | Veglia, Fabrizio | - |
dc.contributor.author | Holdt, Lesca Miriam | - |
dc.contributor.author | Beutner, Frank | - |
dc.contributor.author | Spiering, Wilko | - |
dc.contributor.author | Gansevoort, Ron T. | - |
dc.contributor.author | Navis, Gerjan J. | - |
dc.contributor.author | Breitling, Lutz Philipp H | - |
dc.contributor.author | Brenner, Hermann Hermann | - |
dc.contributor.author | Olsson, Anders G. | - |
dc.contributor.author | Thiery, Joachim J. | - |
dc.contributor.author | Dallmeier, Dhayana | - |
dc.contributor.author | Boer, Jolanda Ma A | - |
dc.contributor.author | Stephens, Jeffrey W. | - |
dc.contributor.author | Hofker, Marten | - |
dc.contributor.author | Tedgui, Alain S. | - |
dc.contributor.author | Watkins, Hugh C. | - |
dc.contributor.author | Hofman, Albert | - |
dc.contributor.author | Uitterlinden, Andre Gerardus | - |
dc.contributor.author | Piťha, Jan | - |
dc.contributor.author | Onland-Moret, N. Charlotte | - |
dc.contributor.author | Ford, Ian | - |
dc.contributor.author | Cramer, Maarten Jan M | - |
dc.contributor.author | Nathoe, H. | - |
dc.contributor.author | Klungel, Olaf H H | - |
dc.contributor.author | Kumari, Meena | - |
dc.contributor.author | Whincup, Peter H. | - |
dc.contributor.author | Morrow, David A. | - |
dc.contributor.author | Morris, Richard W. | - |
dc.contributor.author | Braund, Peter S. | - |
dc.contributor.author | Hall, Alistair S. | - |
dc.contributor.author | Doevendans, Pieter A F M | - |
dc.contributor.author | Trip, Mieke D. | - |
dc.contributor.author | Price, Jackie F. | - |
dc.contributor.author | Tobin, Martin D. | - |
dc.contributor.author | Hamsten, Anders | - |
dc.contributor.author | Koenig, Wolfgang | - |
dc.contributor.author | Nicolaides, Andrew N. | - |
dc.contributor.author | Teupser, Daniel | - |
dc.contributor.author | Day, Ian N.M. | - |
dc.contributor.author | Jukema, Johan Wouter Outer | - |
dc.contributor.author | Carlquist, John F. | - |
dc.contributor.author | Gaunt, Tom R. | - |
dc.contributor.author | Sattar, Naveed A. | - |
dc.contributor.author | Tsimikas, Sotirios | - |
dc.contributor.author | Fox, Keith A.A. | - |
dc.contributor.author | Schwartz, Gregory G. | - |
dc.contributor.author | Lawlor, Debbie A. | - |
dc.contributor.author | Sandhu, Manjinder S. | - |
dc.contributor.author | Poledne, Rudolf | - |
dc.contributor.author | Maitland-van Der Zee, Anke Hilse | - |
dc.contributor.author | Khaw, Kay Tee T | - |
dc.contributor.author | Eriksson, Per Olof | - |
dc.contributor.author | Keating, Brendan J. | - |
dc.contributor.author | Van Der Harst, Pim | - |
dc.contributor.author | Mehta, Shamir R. | - |
dc.contributor.author | Yusuf, Salim M. | - |
dc.contributor.author | Brunisholz, Kimberly D. | - |
dc.contributor.author | Witteman, Jacqueline C M | - |
dc.contributor.author | Franco, Oscar H. | - |
dc.contributor.author | De Knijff, Peter | - |
dc.contributor.author | Tybjærg-Hansen, Anne | - |
dc.contributor.author | Rader, Daniel J. | - |
dc.contributor.author | Farrall, Martin J. | - |
dc.contributor.author | Verschuren, Jeffrey J W | - |
dc.contributor.author | Samani, Nilesh | - |
dc.contributor.author | Kivimaki, Mika | - |
dc.contributor.author | Humphries, Steve Eric | - |
dc.contributor.author | Anderson, Jeffrey L. | - |
dc.contributor.author | Danchin, N. | - |
dc.contributor.author | Boekholdt, S. Matthijs | - |
dc.contributor.author | Palmer, Tom M. | - |
dc.contributor.author | Pare, Guillaume J. | - |
dc.contributor.author | Hingorani, Aroon D. | - |
dc.contributor.author | Sabatine, Marc S. | - |
dc.contributor.author | Mallat, Ziad | - |
dc.contributor.author | Goel, Anuj K. | - |
dc.contributor.author | Casas, Juan Pablo | - |
dc.contributor.author | Talmud, Philippa J. | - |
dc.contributor.author | Mega, Jessica | - |
dc.contributor.author | Van Iperen, Erik P A | - |
dc.contributor.author | Tremoli, Elena | - |
dc.contributor.author | Leusink, Maarten | - |
dc.contributor.author | Trompet, Stella | - |
dc.contributor.author | Hovingh, Gerald Kees | - |
dc.contributor.author | Dehghan, Abbas Jan | - |
dc.contributor.author | Nelson, Christopher P. | - |
dc.contributor.author | Kotti, Salma | - |
dc.contributor.author | Mateo Leach, Irene | - |
dc.contributor.author | Scholz, Markus R. | - |
dc.contributor.author | Haase, Christiane L. | - |
dc.contributor.author | Rothenbacher, Dietrich | - |
dc.contributor.author | Swerdlow, Daniel I. | - |
dc.contributor.author | Franco-Cereceda, Anders | - |
dc.contributor.author | Kuchenbaecker, Karoline B. | - |
dc.contributor.author | Staines-Urias, Eleonora | - |
dc.contributor.author | Van 'T Hooft, Ferdinand M. | - |
dc.contributor.author | Gertow, Karl | - |
dc.contributor.author | De Faire, Ulf H. | - |
dc.contributor.author | Panayiotou, Andrie G. | - |
dc.date.accessioned | 2015-04-20T07:27:40Z | - |
dc.date.accessioned | 2015-12-08T11:10:04Z | - |
dc.date.available | 2015-04-20T07:27:40Z | - |
dc.date.available | 2015-12-08T11:10:04Z | - |
dc.date.issued | 2013-11-19 | - |
dc.identifier.citation | Journal of the American College of Cardiology, 2013, vol. 62, no. 21, pp. 1966-1976 | en_US |
dc.identifier.issn | 15583597 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/3677 | - |
dc.description.abstract | Objectives This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease. Background Higher circulating levels of sPLA2-IIA mass or sPLA 2 enzyme activity have been associated with increased risk of cardiovascular events. However, it is not clear if this association is causal. A recent phase III clinical trial of an sPLA2 inhibitor (varespladib) was stopped prematurely for lack of efficacy. Methods We conducted a Mendelian randomization meta-analysis of 19 general population studies (8,021 incident, 7,513 prevalent major vascular events [MVE] in 74,683 individuals) and 10 acute coronary syndrome (ACS) cohorts (2,520 recurrent MVE in 18,355 individuals) using rs11573156, a variant in PLA2G2A encoding the sPLA2-IIA isoenzyme, as an instrumental variable. Results PLA2G2A rs11573156 C allele associated with lower circulating sPLA2-IIA mass (38% to 44%) and sPLA2 enzyme activity (3% to 23%) per C allele. The odds ratio (OR) for MVE per rs11573156 C allele was 1.02 (95% confidence interval [CI]: 0.98 to 1.06) in general populations and 0.96 (95% CI: 0.90 to 1.03) in ACS cohorts. In the general population studies, the OR derived from the genetic instrumental variable analysis for MVE for a 1-log unit lower sPLA2-IIA mass was 1.04 (95% CI: 0.96 to 1.13), and differed from the non-genetic observational estimate (OR: 0.69; 95% CI: 0.61 to 0.79). In the ACS cohorts, both the genetic instrumental variable and observational ORs showed a null association with MVE. Instrumental variable analysis failed to show associations between sPLA 2 enzyme activity and MVE. Conclusions Reducing sPLA2-IIA mass is unlikely to be a useful therapeutic goal for preventing cardiovascular events. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of the American College of Cardiology | en_US |
dc.rights | © American College of Cardiology Foundation | en_US |
dc.subject | Cardiovascular diseases | en_US |
dc.subject | Drug development | en_US |
dc.subject | Epidemiology | en_US |
dc.subject | Genetics | en_US |
dc.subject | Mendelian randomization | en_US |
dc.title | Secretory phospholipase A2-IIA and cardiovascular disease: a mendelian randomization study | en_US |
dc.type | Article | en_US |
dc.collaboration | University College London | en_US |
dc.collaboration | Hôpital Saint-Antoine | en_US |
dc.collaboration | Université Pierre et Marie Curie | en_US |
dc.collaboration | Karolinska Institutet | en_US |
dc.collaboration | Karolinska University Hospital | en_US |
dc.collaboration | University Medical Center Utrecht | en_US |
dc.collaboration | Durrer Center for Cardiogenetic Research | en_US |
dc.collaboration | Universitat Rovira i Virgili | en_US |
dc.collaboration | Institute for Clinical and Experimental Medicine | en_US |
dc.collaboration | The University of Edinburgh | en_US |
dc.collaboration | Intermountain Medical Center | en_US |
dc.collaboration | University of Utah School of Medicine | en_US |
dc.collaboration | Harvard University | en_US |
dc.collaboration | University of Amsterdam | en_US |
dc.collaboration | University of Pennsylvania | en_US |
dc.collaboration | Utrecht University | en_US |
dc.collaboration | Leiden University | en_US |
dc.collaboration | Erasmus University Rotterdam | en_US |
dc.collaboration | Netherlands Consortium for Healthy Aging | en_US |
dc.collaboration | University of Leicester | en_US |
dc.collaboration | Glenfield Hospital | en_US |
dc.collaboration | Hôpital Européen Georges Pompidou | en_US |
dc.collaboration | Universite Paris | en_US |
dc.collaboration | University of Leipzig | en_US |
dc.collaboration | Copenhagen University Hospital | en_US |
dc.collaboration | Ulm University | en_US |
dc.collaboration | German Cancer Research Center | en_US |
dc.collaboration | University of Cambridge | en_US |
dc.collaboration | London School of Hygiene and Tropical Medicine | en_US |
dc.collaboration | University of Oxford | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | Universitá di Milano | en_US |
dc.collaboration | Centro Cardiologico Monzino | en_US |
dc.collaboration | University Hospital Leipzig | en_US |
dc.collaboration | University of Leipzig | en_US |
dc.collaboration | University Medical Center Groningen | en_US |
dc.collaboration | University of Ulm Medical Center | en_US |
dc.collaboration | Swansea University | en_US |
dc.collaboration | University of Groningen | en_US |
dc.collaboration | Inserm Research Unit | en_US |
dc.collaboration | St George's University of London | en_US |
dc.collaboration | University of Leeds | en_US |
dc.collaboration | Linköping University | en_US |
dc.collaboration | Imperial College London | en_US |
dc.collaboration | Ludwig Maximilians University | en_US |
dc.collaboration | University of Bristol | en_US |
dc.collaboration | University of Glasgow | en_US |
dc.collaboration | University of California | en_US |
dc.collaboration | University of Colorado | en_US |
dc.collaboration | Childrens Hospital of Philadelphia | en_US |
dc.collaboration | McMaster University | en_US |
dc.collaboration | Interuniversity Cardiology Institute of the Netherlands | en_US |
dc.collaboration | Leiden University | en_US |
dc.collaboration | Penn Heart and Vascular Center | en_US |
dc.collaboration | University of Warwick | en_US |
dc.subject.category | Clinical Medicine | en_US |
dc.journals | Subscription | en_US |
dc.review | Peer Reviewed | en |
dc.country | United Kingdom | en_US |
dc.country | France | en_US |
dc.country | Sweden | en_US |
dc.country | Netherlands | en_US |
dc.country | Spain | en_US |
dc.country | Czech Republic | en_US |
dc.country | United States | en_US |
dc.country | Germany | en_US |
dc.country | Cyprus | en_US |
dc.country | Denmark | en_US |
dc.country | Italy | en_US |
dc.country | Canada | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1016/j.jacc.2013.06.044 | en_US |
dc.identifier.pmid | 23916927 | - |
dc.dept.handle | 123456789/108 | en |
dc.relation.issue | 21 | en_US |
dc.relation.volume | 62 | en_US |
cut.common.academicyear | 2013-2014 | en_US |
dc.identifier.spage | 1966 | en_US |
dc.identifier.epage | 1976 | en_US |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.journal.journalissn | 0735-1097 | - |
crisitem.journal.publisher | Elsevier | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0002-6085-568X | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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