Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/3639
DC FieldValueLanguage
dc.contributor.authorAndra, Syam S.-
dc.contributor.authorEttinger, Adrienne S.-
dc.contributor.authorMakris, Konstantinos C.-
dc.contributor.authorChristophi, Costas A.-
dc.date.accessioned2015-03-23T09:06:30Z-
dc.date.accessioned2015-12-08T11:09:26Z-
dc.date.available2015-03-23T09:06:30Z-
dc.date.available2015-12-08T11:09:26Z-
dc.date.issued2013-01-
dc.identifier.citationInternational Journal of Hygiene and Environmental Health, 2013, vol. 216, no. 1, pp. 35–49en_US
dc.identifier.issn14384639-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/3639-
dc.description.abstractNon-carcinogenic effects in low-level (<100 μg L−1) arsenic (As)-impacted populations, such as the development and progression of type-2 diabetes mellitus (T2DM), are often neglected given the primary emphasis of public health authorities on As carcinogenicity. We gathered studies reporting urinary biomarkers of As exposure (U-As) and biomarkers associated with T2DM and its complications (U-T2DM), such as renal damage, oxidation stress, low-grade inflammation, and endothelial damage. Studied U-T2DM biomarkers were: 8-hydroxy-2′deoxyguanosine, N-acetyl-β-d-glucosaminidase, β2-microglobulin, and albumin. Data was expressed as: either arithmetic means and standard deviations, or geometric means and geometric standard deviations, or correlation coefficients of U-As and U-T2DM. Urinary As concentrations were consistently associated with the aforementioned biomarkers of T2DM pathologic complications. Despite the limited selectivity of the selected T2DM biomarkers, a per unit change in As exposure level was reflected in the corresponding T2DM biomarker urinary concentrations. Our systematic review provides new evidence on the role of environmental As exposures influencing the T2DM disease process. Additional epidemiologic studies onto the association between As and T2DM should incorporate both urinary As and T2DM biomarkers, as suggested in this study, in order to evaluate subclinical effects of low-level As exposures.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Hygiene and Environmental Healthen_US
dc.rights© Elsevieren_US
dc.subjectArsenicen_US
dc.subjectDiabetesen_US
dc.subjectRatio of meansen_US
dc.subjectUrinary biomarkersen_US
dc.subject8-Hydroxy-2′ deoxyguanosine, N-acetyl-β-d-glucosaminidaseen_US
dc.subjectβ2-microglobulinen_US
dc.subjectAlbuminen_US
dc.subjectWater and healthen_US
dc.titleDelineating the degree of association between biomarkers of arsenic exposure and type-2 diabetes mellitusen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationYale Universityen_US
dc.collaborationHarvard Universityen_US
dc.subject.categoryBasic Medicineen_US
dc.journalsSubscriptionen_US
dc.reviewPeer Revieweden
dc.countryCyprusen_US
dc.countryUnited Statesen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1016/j.ijheh.2012.07.001en_US
dc.dept.handle123456789/108en
dc.relation.issue1en_US
dc.relation.volume216en_US
cut.common.academicyear2013-2014en_US
dc.identifier.spage35en_US
dc.identifier.epage49en_US
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0001-5251-8619-
crisitem.author.orcid0000-0003-0503-1538-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
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