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Πεδίο DCΤιμήΓλώσσα
dc.contributor.authorMakris, Konstantinos C.-
dc.contributor.authorCharisiadis, Pantelis-
dc.date.accessioned2015-03-20T09:55:24Z-
dc.date.accessioned2015-12-08T11:09:16Z-
dc.date.available2015-03-20T09:55:24Z-
dc.date.available2015-12-08T11:09:16Z-
dc.date.issued2014-02-01-
dc.identifier.citationJournal of Chromatography B, 2014, vol. 947-948, pp. 17-22en_US
dc.identifier.issn15700232-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/3620-
dc.description.abstractBecause of the plethora of exposure sources and routes through which humans are exposed to trihalomethanes (THM), the limitation of their short half-lives could be overcome, if a highly sensitive method was available to quantify urinary THM concentrations at sub-ppb levels. The objective of this study was to develop a fast and reliable method for the determination of the four THM analytes in human urine. A sensitive methodology was developed for THM in urine samples using gas chromatography coupled with triple quadrupole mass spectrometry (GC–QqQ-MS/MS) promoting its use in epidemiological and biomonitoring studies. The proposed methodology enjoys limits of detection similar to those reported in the literature (11–80 ng L−1) and the advantages of small initial urine volumes (15 mL) and fast analysis per sample (12 min) when compared with other methods. This is the first report using GC–QqQ-MS/MS for the determination of THM in urine samples. Because of its simplicity and less time-consuming nature, the proposed method could be incorporated into detailed (hundreds of participants’ urine samples) exposure assessment protocols providing valuable insight into the dose–response relationship of THM and cancer or pregnancy anomalies.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Chromatography Ben_US
dc.rights© Elsevieren_US
dc.subjectChlorineen_US
dc.subjectDisinfection by productsen_US
dc.subjectExposureen_US
dc.subjectMass spectrometryen_US
dc.subjectTrihalomethanesen_US
dc.subjectUrineen_US
dc.titleA sensitive and fast method for trihalomethanes in urine using gas chromatography–triple quadrupole mass spectrometryen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.subject.categoryChemical Sciencesen_US
dc.journalsSubscriptionen_US
dc.reviewPeer Revieweden
dc.countryCyprusen_US
dc.subject.fieldNatural Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1016/j.jchromb.2013.11.060en_US
dc.dept.handle123456789/108en
dc.relation.volume947-948en_US
cut.common.academicyear2013-2014en_US
dc.identifier.spage17en_US
dc.identifier.epage22en_US
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn1570-0232-
crisitem.journal.publisherElsevier-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0001-5251-8619-
crisitem.author.orcid0000-0001-7260-192X-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
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