Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/3616
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yiallouros, Panayiotis K. | - |
dc.contributor.author | Savva, Savvas C. | - |
dc.contributor.author | Kolokotroni, Ourania | - |
dc.contributor.author | Dima, Kleanthi | - |
dc.contributor.author | Zerva, Aikaterini | - |
dc.contributor.author | Kouis, Panagiotis | - |
dc.contributor.author | Bousquet, Jean J. | - |
dc.contributor.author | Middleton, Nicos | - |
dc.date.accessioned | 2015-04-29T10:07:03Z | - |
dc.date.accessioned | 2015-12-08T11:09:12Z | - |
dc.date.available | 2015-04-29T10:07:03Z | - |
dc.date.available | 2015-12-08T11:09:12Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | International Archives of Allergy and Immunology, 2014, vol. 165, no. 2, pp. 91-99 | en_US |
dc.identifier.issn | 14230097 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/3616 | - |
dc.description.abstract | Background: Several studies have examined the relationship of asthma with serum dyslipidemia and reported positive, negative or no association. Most studies were limited by their cross-sectional design and the wide age range of the participants. In a cohort of children in Cyprus, we explored the association of asthma with serum high-density-lipoprotein cholesterol (HDL-C) at age 16-18 years (follow-up) independently of and in relation to HDL-C at age 11-12 years (baseline). Methods: In a case-control design, we recruited active asthmatics (AA; n = 68), current wheezers only (CWO; n = 123) and non-asthmatic controls (n = 660). Logistic regression models were used to evaluate associations of asthma with follow-up serum HDL-C and the role of baseline HDL-C. Results: At follow-up, mean HDL-C levels in AA and CWO patients were significantly lower than in the controls (47.9 and 49.7 vs. 53.4 mg/dl; p = 0.001 and p = 0.011). We observed significant associations of AA patients with low HDL-C (<15th percentile; OR 2.32, 95% CI 1.16-4.47) that remained significant after further adjustment for baseline HDL-C (OR 2.14, 95% CI 1.06-4.14). Stratification by baseline HDL-C indicated that the association was significant only in those with high baseline HDL-C (OR 2.40, 95% CI 1.03-5.20). Stratification by IgE sensitization showed that the association was pronounced only in subjects who were sensitized (OR 3.41, 95% CI 1.12-9.88). Conclusions: Adolescent asthma is associated with low serum HDL-C independent of previous HDL-C levels in childhood. The association appears pronounced in those with a drop in HDL-C levels between childhood and adolescence and in those who have IgE sensitization. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | International Archives of Allergy and Immunology | en_US |
dc.rights | © Karger | en_US |
dc.subject | Asthma | en_US |
dc.subject | Childhood | en_US |
dc.subject | Lipid transfer protein | en_US |
dc.subject | Pediatric allergy | en_US |
dc.title | Asthma: the role of low high-density-lipoprotein cholesterol in childhood and adolescence | en_US |
dc.type | Article | en_US |
dc.collaboration | Universitaire Arnaud de Villeneuve | en_US |
dc.collaboration | Attikon University Hospital | en_US |
dc.collaboration | University of Nicosia | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.subject.category | Clinical Medicine | en_US |
dc.journals | Subscription | en_US |
dc.review | Peer Reviewed | en |
dc.country | France | en_US |
dc.country | Greece | en_US |
dc.country | Cyprus | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.identifier.doi | 10.1159/000368405 | en_US |
dc.dept.handle | 123456789/108 | en |
dc.relation.issue | 2 | en_US |
dc.relation.volume | 165 | en_US |
cut.common.academicyear | 2014-2015 | en_US |
dc.identifier.spage | 91 | en_US |
dc.identifier.epage | 99 | en_US |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.journal.journalissn | 1423-0097 | - |
crisitem.journal.publisher | Karger | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.dept | Department of Nursing | - |
crisitem.author.dept | Department of Nursing | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0002-8339-9285 | - |
crisitem.author.orcid | 0000-0002-7653-002X | - |
crisitem.author.orcid | 0000-0001-6358-8591 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Appears in Collections: | Άρθρα/Articles |
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