Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/3616
DC FieldValueLanguage
dc.contributor.authorYiallouros, Panayiotis K.-
dc.contributor.authorSavva, Savvas C.-
dc.contributor.authorKolokotroni, Ourania-
dc.contributor.authorDima, Kleanthi-
dc.contributor.authorZerva, Aikaterini-
dc.contributor.authorKouis, Panagiotis-
dc.contributor.authorBousquet, Jean J.-
dc.contributor.authorMiddleton, Nicos-
dc.date.accessioned2015-04-29T10:07:03Z-
dc.date.accessioned2015-12-08T11:09:12Z-
dc.date.available2015-04-29T10:07:03Z-
dc.date.available2015-12-08T11:09:12Z-
dc.date.issued2014-12-
dc.identifier.citationInternational Archives of Allergy and Immunology, 2014, vol. 165, no. 2, pp. 91-99en_US
dc.identifier.issn14230097-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/3616-
dc.description.abstractBackground: Several studies have examined the relationship of asthma with serum dyslipidemia and reported positive, negative or no association. Most studies were limited by their cross-sectional design and the wide age range of the participants. In a cohort of children in Cyprus, we explored the association of asthma with serum high-density-lipoprotein cholesterol (HDL-C) at age 16-18 years (follow-up) independently of and in relation to HDL-C at age 11-12 years (baseline). Methods: In a case-control design, we recruited active asthmatics (AA; n = 68), current wheezers only (CWO; n = 123) and non-asthmatic controls (n = 660). Logistic regression models were used to evaluate associations of asthma with follow-up serum HDL-C and the role of baseline HDL-C. Results: At follow-up, mean HDL-C levels in AA and CWO patients were significantly lower than in the controls (47.9 and 49.7 vs. 53.4 mg/dl; p = 0.001 and p = 0.011). We observed significant associations of AA patients with low HDL-C (<15th percentile; OR 2.32, 95% CI 1.16-4.47) that remained significant after further adjustment for baseline HDL-C (OR 2.14, 95% CI 1.06-4.14). Stratification by baseline HDL-C indicated that the association was significant only in those with high baseline HDL-C (OR 2.40, 95% CI 1.03-5.20). Stratification by IgE sensitization showed that the association was pronounced only in subjects who were sensitized (OR 3.41, 95% CI 1.12-9.88). Conclusions: Adolescent asthma is associated with low serum HDL-C independent of previous HDL-C levels in childhood. The association appears pronounced in those with a drop in HDL-C levels between childhood and adolescence and in those who have IgE sensitization.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofInternational Archives of Allergy and Immunologyen_US
dc.rights© Kargeren_US
dc.subjectAsthmaen_US
dc.subjectChildhooden_US
dc.subjectLipid transfer proteinen_US
dc.subjectPediatric allergyen_US
dc.titleAsthma: the role of low high-density-lipoprotein cholesterol in childhood and adolescenceen_US
dc.typeArticleen_US
dc.collaborationUniversitaire Arnaud de Villeneuveen_US
dc.collaborationAttikon University Hospitalen_US
dc.collaborationUniversity of Nicosiaen_US
dc.collaborationCyprus University of Technologyen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsSubscriptionen_US
dc.reviewPeer Revieweden
dc.countryFranceen_US
dc.countryGreeceen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.identifier.doi10.1159/000368405en_US
dc.dept.handle123456789/108en
dc.relation.issue2en_US
dc.relation.volume165en_US
cut.common.academicyear2014-2015en_US
dc.identifier.spage91en_US
dc.identifier.epage99en_US
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn1423-0097-
crisitem.journal.publisherKarger-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.deptDepartment of Nursing-
crisitem.author.deptDepartment of Nursing-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0002-8339-9285-
crisitem.author.orcid0000-0002-7653-002X-
crisitem.author.orcid0000-0001-6358-8591-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
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