Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/3304
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Farantos, Stavros C. | - |
dc.contributor.author | Guallar, Victor | - |
dc.contributor.author | Varotsis, Constantinos | - |
dc.contributor.author | Daskalakis, Vangelis | - |
dc.contributor.author | Farantos, Stavros C. | - |
dc.date.accessioned | 2013-01-16T13:43:23Z | en |
dc.date.accessioned | 2013-05-17T07:13:15Z | - |
dc.date.accessioned | 2015-12-08T07:52:53Z | - |
dc.date.available | 2013-01-16T13:43:23Z | en |
dc.date.available | 2013-05-17T07:13:15Z | - |
dc.date.available | 2015-12-08T07:52:53Z | - |
dc.date.issued | 2011-04-07 | - |
dc.identifier.citation | Journal of Physical Chemistry B, vol. 115, no. 13, pp. 3648-3655 | en_US |
dc.identifier.issn | 15205207 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/3304 | - |
dc.description.abstract | Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of molecular oxygen to water and couples this reduction to the pumping of four protons through the protein matrix. Water molecules inside the protein are involved in the proton pumping activity as proton carriers. A highly conserved water molecule, among different CcO enzymes, lies between the heme a 3 propionates. Here, we show, by quantum mechanical/molecular mechanical (QM/MM) simulations, that this conserved water molecule can transfer its proton to propionate-A. His403 residue coordinates to the Mg site near the so-called water pool. By both QM/MM and molecular dynamics calculations, we demonstrate that the also conserved His403 residue, adjacent to the heme a 3 propionate-A, plays a role of a valve controlling the protonation state of the propionate-A/Asp399 pair. This, in turn, controls the oxidation state of the heme a 3 iron, linking in this way, the D-proton pathway to the water pool | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | The Journal of Physical Chemistry B | en_US |
dc.rights | © American Chemical Society | en_US |
dc.subject | Electron Transport Complex IV | en_US |
dc.subject | Heme | en_US |
dc.subject | Heme a3 | en_US |
dc.title | Regulation of electron and proton transfer by the protein matrix of cytochrome C oxidase | en_US |
dc.type | Article | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | Foundation for Research & Technology-Hellas (F.O.R.T.H.) | en_US |
dc.collaboration | University of Crete | en_US |
dc.collaboration | Barcelona Supercomputing Center | en_US |
dc.subject.category | Chemical Sciences | en_US |
dc.subject.category | ENGINEERING AND TECHNOLOGY | en_US |
dc.journals | Subscription | en_US |
dc.review | peer reviewed | - |
dc.country | Greece | en_US |
dc.country | Spain | en_US |
dc.country | Cyprus | en_US |
dc.subject.field | Engineering and Technology | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1021/jp1115993 | en_US |
dc.dept.handle | 123456789/77 | en |
dc.relation.issue | 13 | en_US |
dc.relation.volume | 115 | en_US |
cut.common.academicyear | 2010-2011 | en_US |
dc.identifier.spage | 3648 | en_US |
dc.identifier.epage | 3655 | en_US |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Department of Chemical Engineering | - |
crisitem.author.dept | Department of Chemical Engineering | - |
crisitem.author.faculty | Faculty of Geotechnical Sciences and Environmental Management | - |
crisitem.author.faculty | Faculty of Geotechnical Sciences and Environmental Management | - |
crisitem.author.orcid | 0000-0003-2771-8891 | - |
crisitem.author.orcid | 0000-0001-8870-0850 | - |
crisitem.author.parentorg | Faculty of Geotechnical Sciences and Environmental Management | - |
crisitem.author.parentorg | Faculty of Geotechnical Sciences and Environmental Management | - |
crisitem.journal.journalissn | 1520-5207 | - |
crisitem.journal.publisher | American Chemical Society | - |
Appears in Collections: | Άρθρα/Articles |
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