The origin of the FeIV = O intermediates in cytochrome aa3 oxidase
Journal
Biochimica et Biophysica Acta - Bioenergetics
Date Issued
April 2012
DOI
10.1016/j.bbabio.2011.07.009
Abstract
The dioxygen reduction mechanism in cytochrome oxidases relies on proton control of the electron transfer events that drive the process. Proton delivery and proton channels in the protein that are relevant to substrate reduction and proton pumping are considered, and the current status of this area is summarized. We propose a mechanism in which the coupling of the oxygen reduction chemistry to proton translocation (P → F transition) is related to the properties of two groups of highly conserved residues, namely, His411/G386-T389 and the heme a 3-propionateA-D399-H403 chain. This article is part of a Special Issue entitled: Respiratory Oxidases