Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/30711
DC FieldValueLanguage
dc.contributor.authorPapachristodoulou, Eleni-
dc.contributor.authorKakoullis, Loukas-
dc.contributor.authorChristophi, Costas A.-
dc.contributor.authorPsarelis, Savvas-
dc.contributor.authorHajiroussos, Victor-
dc.contributor.authorParperis, Konstantinos-
dc.date.accessioned2023-10-30T09:37:22Z-
dc.date.available2023-10-30T09:37:22Z-
dc.date.issued2023-10-
dc.identifier.citationRheumatology International, vol. 43, iss. 10, pp. 1841 - 1848en_US
dc.identifier.issn01728172-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/30711-
dc.description.abstractThe neutrophil-to-lymphocyte ratio (NLR) emerged as a potential biomarker in SLE, but its association with several outcomes remains unclear. We aimed to evaluate the relationship between NLR and SLE disease activity, damage, depression, and health-related quality of life. A cross-sectional study was conducted, including 134 patients with SLE who visited the Division of Rheumatology between November 2019 and June 2021. Demographics and clinical data including NLR, Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus disease activity index (SELENA-SLEDAI), Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), physician global assessment (PhGA), patient global assessment (PGA), patient health questionnaire (PHQ)-9, patient self-rated health, and lupus quality of life (LupusQoL) scores, were collected. Patients were stratified into two groups and compared using the NLR cut-off of 2.73, the 90th percentile value of healthy individuals. The analysis included t-test for continuous variables, χ2-test for categorical variables, and logistic regression adjusting for age, sex, BMI, and glucocorticoid use. Among the 134 SLE patients, 47 (35%) had an NLR ≥ 2.73. The NLR ≥ 2.73 group had significantly higher rates of severe depression (PHQ ≥ 15), poor/fair self-rated health, and the presence of damage (SDI ≥ 1). These patients also scored significantly lower in LupusQoL domains (physical health, planning, and body image), and higher in SELENA-SLEDAI, PhGA, and PGA. Logistic regression confirmed that high NLR is associated with severe depression (PHQ ≥ 15) (OR:7.23, 2.03-25.74), poor/fair self-rated health (OR:2.77,1.29-5.96), high SELENA-SLEDAI score(≥ 4) (OR:2.22,1.03-4.78), high PhGA (≥ 2) (OR:3.76, 1.56-9.05), and presence of damage (SDI ≥ 1) (OR:2.67, 1.11-6.43). High NLR in SLE may indicate depression, worse quality of life, active disease, and the presence of damage.en_US
dc.language.isoenen_US
dc.relation.ispartofRheumatology internationalen_US
dc.rights© The Author(s).en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiomarkeren_US
dc.subjectDepressionen_US
dc.subjectQuality of lifeen_US
dc.subjectSystemic lupus erythematosusen_US
dc.titleThe relationship of neutrophil-to-lymphocyte ratio with health-related quality of life, depression, and disease activity in SLE: a cross-sectional studyen_US
dc.typeArticleen_US
dc.collaborationMedical School University of Cyprusen_US
dc.collaborationUniversity of Patrasen_US
dc.collaborationMount Auburn Hospitalen_US
dc.collaborationHarvard Medical Schoolen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationYgia Polyclinic Hospitalen_US
dc.subject.categoryHealth Sciencesen_US
dc.journalsSubscriptionen_US
dc.countryCyprusen_US
dc.countryGreeceen_US
dc.countryUnited Statesen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1007/s00296-023-05381-8en_US
dc.identifier.pmid37405441-
dc.identifier.scopus2-s2.0-85164189203-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85164189203-
dc.relation.issue10en_US
dc.relation.volume43en_US
cut.common.academicyear2022-2023en_US
dc.identifier.spage1841en_US
dc.identifier.epage1848en_US
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0003-0503-1538-
crisitem.author.parentorgFaculty of Health Sciences-
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