Παρακαλώ χρησιμοποιήστε αυτό το αναγνωριστικό για να παραπέμψετε ή να δημιουργήσετε σύνδεσμο προς αυτό το τεκμήριο: https://hdl.handle.net/20.500.14279/29915
Πεδίο DCΤιμήΓλώσσα
dc.contributor.authorAntoniou, Anastasia-
dc.contributor.authorNikolaou, Anastasia-
dc.contributor.authorGeorgiou, Andreas-
dc.contributor.authorEvripidou, Nikolas-
dc.contributor.authorDamianou, Christakis A.-
dc.date.accessioned2023-07-20T08:00:28Z-
dc.date.available2023-07-20T08:00:28Z-
dc.date.issued2023-05-
dc.identifier.citationUltrasonics, 2023, vol. 131, pp. 1-10en_US
dc.identifier.issn0041624X-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/29915-
dc.description.abstractTissue mimicking phantoms (TMPs) play an essential role in modern biomedical research as cost-effective quality assurance and training tools, simultaneously contributing to the reduction of animal use. Herein, we present the development and evaluation of an anatomically accurate mouse phantom intended for image-guided thermal ablation and Focused Ultrasound (FUS) applications. The proposed mouse model consists of skeletal and soft tissue mimics, whose design was based on the Computed tomography (CT) scans data of a live mouse. Advantageously, it is compatible with US, CT, and Magnetic Resonance Imaging (MRI). The compatibility assessment was focused on the radiological behavior of the phantom due to the lack of relevant literature. The X-ray linear attenuation coefficient of candidate materials was estimated to assess the one that matches best the radiological behavior of living tissues. The bone part was manufactured by Fused Deposition Modeling (FDM) printing using Acrylonitrile styrene acrylate (ASA) material. For the soft-tissue mimic, a special mold was 3D printed having a cavity with the unique shape of the mouse body and filled with an agar-based silica-doped gel. The mouse phantom accurately matched the size and reproduced the body surface of the imaged mouse. Tissue-equivalency in terms of X-ray attenuation was demonstrated for the agar-based soft-tissue mimic. The phantom demonstrated excellent MRI visibility of the skeletal and soft-tissue mimics. Good radiological contrast between the skeletal and soft-tissue models was also observed in the CT scans. The model was also able to reproduce realistic behavior during trans-skull sonication as proved by thermocouple measurements. Overall, the proposed phantom is inexpensive, ergonomic, and realistic. It could constitute a powerful tool for image-guided thermal ablation and FUS studies in terms of testing and optimizing the performance of relevant equipment and protocols. It also possess great potential for use in transcranial FUS applications, including the emerging topic of FUS-mediated blood brain barrier (BBB) disruption.en_US
dc.language.isoenen_US
dc.relation.ispartofUltrasonicsen_US
dc.rights© Elsevier B.V. All rights reserved.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectCTen_US
dc.subjectMRIen_US
dc.subjectMouseen_US
dc.subjectPhantomen_US
dc.subjectUltrasounden_US
dc.titleDevelopment of an US, MRI, and CT imaging compatible realistic mouse phantom for thermal ablation and focused ultrasound evaluationen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.subject.categoryElectrical Engineering - Electronic Engineering - Information Engineeringen_US
dc.journalsSubscriptionen_US
dc.countryCyprusen_US
dc.subject.fieldEngineering and Technologyen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1016/j.ultras.2023.106955en_US
dc.identifier.pmid36854247-
dc.identifier.scopus2-s2.0-85148890352-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85148890352-
dc.relation.volume131en_US
cut.common.academicyear2022-2023en_US
dc.identifier.spage1en_US
dc.identifier.epage10en_US
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn0041-624X-
crisitem.journal.publisherElsevier-
crisitem.author.deptDepartment of Electrical Engineering, Computer Engineering and Informatics-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.orcid0000-0003-0424-2851-
crisitem.author.parentorgFaculty of Engineering and Technology-
Εμφανίζεται στις συλλογές:Άρθρα/Articles
CORE Recommender
Δείξε τη σύντομη περιγραφή του τεκμηρίου

SCOPUSTM   
Citations

1
checked on 2 Φεβ 2024

WEB OF SCIENCETM
Citations

1
Last Week
0
Last month
0
checked on 1 Νοε 2023

Page view(s)

198
Last Week
0
Last month
34
checked on 14 Μαρ 2025

Google ScholarTM

Check

Altmetric


Αυτό το τεκμήριο προστατεύεται από άδεια Άδεια Creative Commons Creative Commons