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Πεδίο DCΤιμήΓλώσσα
dc.contributor.authorTraikapi, Artemis-
dc.contributor.authorKalli, Ioanna-
dc.contributor.authorKyriakou, Andrea-
dc.contributor.authorStylianou, Elena-
dc.contributor.authorSymeou, Rafaella Tereza-
dc.contributor.authorKardama, Akrivi-
dc.contributor.authorChristou, Yiolanda Panayiota-
dc.contributor.authorPhylactou, Phivos-
dc.contributor.authorKonstantinou, Nikos-
dc.date.accessioned2023-07-13T07:24:08Z-
dc.date.available2023-07-13T07:24:08Z-
dc.date.issued2023-06-
dc.identifier.citationJournal of Neuropsychology, 2023, vol. 17, iss. 2, pp. 279 - 301en_US
dc.identifier.issn17486645-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/29833-
dc.description.abstractEpisodic memory decline is the prominent neuropsychological feature of typical Alzheimer's Disease (AD), for which current treatments have a limited clinical response. Recently, gamma entrainment therapy has been used as a non-invasive treatment in AD, providing evidence that it may have the potential to alleviate brain pathology and improve cognitive function in AD patients. At the same time, the precuneus (PC) has been recognized as a key area involved in AD related memory deficits and as a key node of the Default Mode Network. This study aimed to investigate the effectiveness of a 40 Hz Transcranial Magnetic Stimulation (TMS) intervention, delivered bilaterally to the precuneus for 10 days, in improving the patients' episodic memory performance. Secondary outcome variables investigated included general cognitive function, semantic and spatial memory, as well as attention and executive function. A concurrent multiple baseline design across five cases was employed. Four patients completed the study. Visual analysis combined with effect size indices were used to evaluate changes across phases. An increase in the average level of immediate recalled words was observed in three out of four patients. Effect size indices indicated significant improvement of attention skills in two patients. No treatment effect was observed for semantic and visual memory, or for executive function. An immediate treatment effect was observed in all patients' general cognitive function as assessed with the Alzheimer's Disease Assessment Scale (mean reduction of 5 points), which was maintained and improved further three months post-treatment. The neuropsychological evaluations indicated improved performance three months post-treatment in immediate and delayed recall, attention, phonological verbal fluency, anxiety, and neuropsychiatric symptoms. This study provides preliminary evidence for the efficacy of a novel non-pharmacological treatment using gamma-band TMS in addressing cognitive dysfunction in AD.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of neuropsychologyen_US
dc.rights© The Authorsen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlzheimer's Diseaseen_US
dc.subjectepisodic memoryen_US
dc.subjectgamma frequency brain stimulationen_US
dc.subjectprecuneusen_US
dc.subjecttranscranial magnetic stimulationen_US
dc.titleEpisodic memory effects of gamma frequency precuneus transcranial magnetic stimulation in Alzheimer's disease: A randomized multiple baseline studyen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationRehabilitation Center Melathron Agoniston EOKAen_US
dc.collaborationAcropoleos Medical Centeren_US
dc.subject.categoryChemical Engineeringen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.subject.fieldEngineering and Technologyen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1111/jnp.12299en_US
dc.identifier.pmid36351687-
dc.identifier.scopus2-s2.0-85141777281-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85141777281-
dc.relation.issue2en_US
dc.relation.volume17en_US
cut.common.academicyear2022-2023en_US
dc.identifier.spage279en_US
dc.identifier.epage301en_US
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0003-4531-3636-
crisitem.author.parentorgFaculty of Health Sciences-
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