Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/29666
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tarazona, Jose V | - |
dc.contributor.author | Cattaneo, Irene | - |
dc.contributor.author | Niemann, Lars | - |
dc.contributor.author | Pedraza-Diaz, Susana | - |
dc.contributor.author | González-Caballero, Maria Carmen | - |
dc.contributor.author | de Alba-Gonzalez, Mercedes | - |
dc.contributor.author | Cañas, Ana | - |
dc.contributor.author | Dominguez-Morueco, Noelia | - |
dc.contributor.author | López, Marta Esteban | - |
dc.contributor.author | Castaño, Argelia | - |
dc.contributor.author | Borges, Teresa | - |
dc.contributor.author | Katsonouri, Andromachi | - |
dc.contributor.author | Makris, Konstantinos C. | - |
dc.contributor.author | Ottenbros, Ilse | - |
dc.contributor.author | Mol, Hans | - |
dc.contributor.author | De Decker, Annelies | - |
dc.contributor.author | Morrens, Bert | - |
dc.contributor.author | Berman, Tamar | - |
dc.contributor.author | Barnett-Itzhaki, Zohar | - |
dc.contributor.author | Probst-Hensch, Nicole | - |
dc.contributor.author | Fuhrimann, Samuel | - |
dc.contributor.author | Tratnik, Janja Snoj | - |
dc.contributor.author | Horvat, Milena | - |
dc.contributor.author | Rambaud, Loïc | - |
dc.contributor.author | Riou, Margaux | - |
dc.contributor.author | Schoeters, Greet | - |
dc.contributor.author | Govarts, Eva | - |
dc.contributor.author | Kolossa-Gehring, Marike | - |
dc.contributor.author | Weber, Till | - |
dc.contributor.author | Apel, Petra | - |
dc.contributor.author | Namorado, Sonia | - |
dc.contributor.author | Santonen, Tiina | - |
dc.date.accessioned | 2023-07-05T11:22:48Z | - |
dc.date.available | 2023-07-05T11:22:48Z | - |
dc.date.issued | 2022-08-04 | - |
dc.identifier.citation | Toxics, 2022, vol. 10, iss. 8 | en_US |
dc.identifier.issn | 23056304 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/29666 | - |
dc.description.abstract | Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches and more specific metabolites were used for refining the risk estimates. Exposure was based on 95th percentiles from HBM4EU aligned studies (2014-2021) covering children in Belgium, Cyprus, France, Israel, Slovenia, and The Netherlands and adults in France, Germany, Israel, and Switzerland. In all children populations, the 95th percentiles for 3-phenoxybenzoic acid (3-PBA) exceeded the screening value. The probabilistic refinement quantified the risk level of the most exposed population (Belgium) at 2% or between 1-0.1% depending on the assumptions. In the substance specific assessments, the 95th percentiles of urinary concentrations in the aligned studies were well below the respective human biomonitoring guidance values (HBM-GVs). Both information sets were combined for refining the combined risk. Overall, the HBM data suggest a low health concern, at population level, related to pyrethroid exposure for the populations covered by the studies, even though a potential risk for highly exposed children cannot be completely excluded. The proposed tiered approach, including a screening step and several refinement options, seems to be a promising tool of scientific and regulatory value in future. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.rights | © by the authors | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | biocides | en_US |
dc.subject | combined pyrethroid risk assessment | en_US |
dc.subject | guidance values | en_US |
dc.subject | HBM4EU | en_US |
dc.subject | human biomonitoring | en_US |
dc.subject | pesticides | en_US |
dc.subject | pyrethroids | en_US |
dc.subject | screening assessment | en_US |
dc.subject | tiered approach | en_US |
dc.subject | veterinary drugs | en_US |
dc.title | A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data | en_US |
dc.type | Article | en_US |
dc.collaboration | European Food Safety Authority | en_US |
dc.collaboration | Instituto de Salud Carlos III | en_US |
dc.collaboration | German Federal Institute for Risk Assessment | en_US |
dc.collaboration | Ministry of Health | en_US |
dc.collaboration | Cyprus Ministry of Health | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | National Institute for Public Health and the Environment (RIVM) | en_US |
dc.collaboration | Wageningen Food Safety Research | en_US |
dc.collaboration | Knowledge Center for Environment and Health | en_US |
dc.collaboration | University of Antwerp | en_US |
dc.collaboration | Ruppin Academic Center | en_US |
dc.collaboration | Swiss Tropical and Public Health Institute | en_US |
dc.collaboration | Jožef Stefan Institute | en_US |
dc.collaboration | Santé Publique France | en_US |
dc.collaboration | Flemish Institute for Technological Research (VITO) | en_US |
dc.collaboration | German Environment Agency (UBA) | en_US |
dc.collaboration | National Institute of Health Dr. Ricardo Jorge | en_US |
dc.collaboration | Finnish Institute of Occupational Health | en_US |
dc.subject.category | Health Sciences | en_US |
dc.journals | Open Access | en_US |
dc.country | Italy | en_US |
dc.country | Spain | en_US |
dc.country | Germany | en_US |
dc.country | Portugal | en_US |
dc.country | Cyprus | en_US |
dc.country | Netherlands | en_US |
dc.country | Belgium | en_US |
dc.country | Israel | en_US |
dc.country | Switzerland | en_US |
dc.country | Slovenia | en_US |
dc.country | France | en_US |
dc.country | Finland | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.3390/toxics10080451 | en_US |
dc.identifier.pmid | 36006130 | - |
dc.identifier.scopus | 2-s2.0-85137320961 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85137320961 | - |
dc.relation.issue | 8 | en_US |
dc.relation.volume | 10 | en_US |
cut.common.academicyear | 2021-2022 | en_US |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0001-5251-8619 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Appears in Collections: | Άρθρα/Articles |
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makris constantinos 6.pdf | Full text | 1.74 MB | Adobe PDF | View/Open |
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