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Πεδίο DCΤιμήΓλώσσα
dc.contributor.authorIoannou, Elina-
dc.contributor.authorOikonomou, Stavros-
dc.contributor.authorEuthymiou, Nikolaos-
dc.contributor.authorConstantinou, Andria-
dc.contributor.authorDelplancke, Thibaut-
dc.contributor.authorCharisiadis, Pantelis-
dc.contributor.authorMakris, Konstantinos C.-
dc.date.accessioned2023-07-05T07:07:16Z-
dc.date.available2023-07-05T07:07:16Z-
dc.date.issued2023-02-17-
dc.identifier.citationiScience, 2023, vol. 26, iss. 2en_US
dc.identifier.issn25890042-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/29644-
dc.description.abstractTailoring medical models to the right person or risk subgroups delivered at the right time is important in personalized medicine/prevention initiatives. The CIRCA-CHEM randomized 2x2 crossover pilot trial investigated whether the consumption of fruits/vegetables within a time-restricted daily window would affect urinary biomarkers of exposure to neonicotinoids (6-chloronicotinic acid, 6-CN) and pyrethroids (3-phenoxybenzoic acid, 3-PBA) pesticides, a biomarker of oxidative damage (4-hydroxynonenal, 4-HNE) and the associated urinary NMR metabolome. A statistically significant difference (p < 0.001) in both creatinine-adjusted 6-CN and 3-PBA levels was observed between the two-time dietary intervention windows (morning vs. evening). In the evening intervention period, pesticides biomarker levels were higher compared to the baseline, whereas in the morning period, pesticide levels remained unchanged. Positive associations were observed between pesticides and 4-HNE suggesting a diurnal chrono-window of pesticide toxicity. The discovery of a chronotoxicity window associated with chrono-disrupted metabolism of food contaminants may find use in personalized medicine initiatives.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofiScienceen_US
dc.rights© The Author(s)en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectExposure assessmenten_US
dc.subjectFood scienceen_US
dc.subjectToxicologyen_US
dc.titleA time differentiated dietary intervention effect on the biomarkers of exposure to pyrethroids and neonicotinoids pesticidesen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationState Health Services Organization, Republic of Cyprusen_US
dc.subject.categoryHealth Sciencesen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1016/j.isci.2022.105847en_US
dc.identifier.pmid36711241-
dc.identifier.scopus2-s2.0-85146952742-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85146952742-
dc.relation.issue2en_US
dc.relation.volume26en_US
cut.common.academicyear2022-2023en_US
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0001-7260-192X-
crisitem.author.orcid0000-0001-5251-8619-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
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