Inorganic nanoparticles for biomedical & technological applications
Date Issued
October 2022
Author(s)
Abstract
Magnetic nanoparticle (MNP)-based theranostics are emerging
as important tools for diagnosis and treatment (theranostics) of
various cancer types, and bone disorders. Synthesis of MNPs
who can act as Magnetic Resonance Imaging contrast agents
with high relaxivity and low toxicity is one of the major prerequisite in the field of theranostics [1].
Also, such applications require magnetic nanoparticles with
well-defined composition, narrow size distribution, and high
saturation magnetization values for enhanced interaction with
an externally applied magnetic field. Spinel ferrites with the
general formula MFe2O4 (M = Mn, Fe, Co, Ni) have been
proposed among others to act of MRI contrast enhancement
agents among other types of MNPs based on both transition
metal ions and rare earth elements in the presence of various
organic moieties, polymers, ligands, etc [2,3].
A facile solvothermal approach was used to synthesize stable
ferrite nanoparticles as a simple and eco-friendly route,
providing though products that exhibit high crystallinity in the
presence of well-defined polymers and/or organic ligands. The
hydrophobic MNPs converted to hydrophilic and the
hyperthermic effects as well as relaxometric properties were
studied and evaluated. Hydrophobic MFe2O4 nanoparticles coated
with oleylamine (MFe2O4@OAm MNPs, where M = Co, Mn, Ni)
with a similar shape and size (∼9 nm) and magnetization values of
87.4, 63.1 and 55.0 emu g−1 for CoFe2O4@OAm,
MnFe2O4@OAm and NiFe2O4@OAm, respectively, were
successfully encapsulated into the hydrophobic cores of spherical
micellar structures formed by the copolymers in an aqueous
solution through a solvent mixing procedure [4,5].
as important tools for diagnosis and treatment (theranostics) of
various cancer types, and bone disorders. Synthesis of MNPs
who can act as Magnetic Resonance Imaging contrast agents
with high relaxivity and low toxicity is one of the major prerequisite in the field of theranostics [1].
Also, such applications require magnetic nanoparticles with
well-defined composition, narrow size distribution, and high
saturation magnetization values for enhanced interaction with
an externally applied magnetic field. Spinel ferrites with the
general formula MFe2O4 (M = Mn, Fe, Co, Ni) have been
proposed among others to act of MRI contrast enhancement
agents among other types of MNPs based on both transition
metal ions and rare earth elements in the presence of various
organic moieties, polymers, ligands, etc [2,3].
A facile solvothermal approach was used to synthesize stable
ferrite nanoparticles as a simple and eco-friendly route,
providing though products that exhibit high crystallinity in the
presence of well-defined polymers and/or organic ligands. The
hydrophobic MNPs converted to hydrophilic and the
hyperthermic effects as well as relaxometric properties were
studied and evaluated. Hydrophobic MFe2O4 nanoparticles coated
with oleylamine (MFe2O4@OAm MNPs, where M = Co, Mn, Ni)
with a similar shape and size (∼9 nm) and magnetization values of
87.4, 63.1 and 55.0 emu g−1 for CoFe2O4@OAm,
MnFe2O4@OAm and NiFe2O4@OAm, respectively, were
successfully encapsulated into the hydrophobic cores of spherical
micellar structures formed by the copolymers in an aqueous
solution through a solvent mixing procedure [4,5].
Subjects
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