Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/26549
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dc.contributor.authorKapnisis, Konstantinos-
dc.contributor.authorHalwani, Dina O.-
dc.contributor.authorBrott, Brigitta C.-
dc.contributor.authorAnderson, Peter G.-
dc.contributor.authorLemons, Jack E.-
dc.contributor.authorAnayiotos, Andreas-
dc.date.accessioned2022-04-05T09:39:13Z-
dc.date.available2022-04-05T09:39:13Z-
dc.date.issued2010-07-08-
dc.identifier.citation2nd International Conferences on Recent Advances in Health and Medical Sciences, 8-12 July, Paphos, Cyprusen_US
dc.identifier.urihttps://hdl.handle.net/20.500.14279/26549-
dc.description.abstractIntroduction: Preliminary studies have revealed that stainless steel (SS) and nickel titanium (NiTi) stents undergo corrosion in vivo, with significant release of metallic ions into surrounding tissues. It is believed that high concentrations of metal ions from both SS and NiTi stents are toxic to vascular smooth muscle cells and stimulate both inflammatory and fibrotic reactions leading to neointimal formation and a predisposition to device failure. To separate the mechanical effects from the local environmental effects on the stent surface, in-vitro mechanical studies were performed on various combinations of stents under low and high curvature and in overlapping positions to compare the results of fretting, pitting and gouging with the explanted stents. Methods: Accelerated biomechanical studies were performed on SS, NiTi and Cobalt-Chromium (CoCr) stents using Bose®ElectroForce®9110 Stent/Graft Test (Bose Corporation, Bethel, WA) mechanical testing instrument. The stents were deployed in latex tubing mock arteries and the system was exposed to flow of saline representative of coronary flow under physiologic wall motion 5-10% and was programmed to perform several million of cycles to simulate several years of operation. The tested stents underwent surface evaluation by Scanning Electron Microscope (SEM) and optical microscope Keyence to identify locations of pitting, fretting and cracking phenomena due to interfacial conditions. Results: Wear features were observed on the stents surface in both straight and low curvature modes especially in the overlapping cases where we observed localized fret features in the areas where there is significant crossing of the wire from both stents. Fracture was also observed in addition to fretting features on both the NiTi and CoCr stents placed in a curved latex tube at 40% overlap under 104 million cycles. Fracture surfaces show a fatigue mechanism. Discussion and conclusion: In some occasions the fretting features from cadaver specimens were similar to the fretting features from the mechanical studies. High curvature and the factor of stent overlap increased the corroded regions and the degree of corrosion. This will provide insights into the mechanisms of stent corrosion and vascular responses and indicate possible cause-effect relationships for biological reactions leading to restenosis.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectStainless steel stentsen_US
dc.subjectNickel titanium stentsen_US
dc.titleBiocorrosion and biomechanical analysis of explant devicesen_US
dc.typeConference Papersen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationUniversity of Alabama at Birminghamen_US
dc.subject.categoryMaterials Engineeringen_US
dc.countryCyprusen_US
dc.countryUnited Statesen_US
dc.subject.fieldEngineering and Technologyen_US
dc.publicationPeer Revieweden_US
dc.relation.conferenceInternational Conference on Recent Advances in Health and Medical Sciencesen_US
cut.common.academicyear2009-2010en_US
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_c94f-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeconferenceObject-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.orcid0000-0002-4999-0231-
crisitem.author.orcid0000-0003-4471-7604-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
Appears in Collections:Δημοσιεύσεις σε συνέδρια /Conference papers or poster or presentation
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