Lymphocyte Nanomechanics in Response to Stent Implantation
Date Issued
June 14, 2021
Abstract
Changes in the arterial mechanical environment due to stent
implantation are the main causes of the initiation of thrombosis and
restenosis [1]. The mechanical properties of live cells can affect their
physical interactions with the surrounding extracellular matrix,
potentially influencing the process of mechanical signal transduction in
living tissues. Previous studies have described the infiltration of
inflammatory cells and immunocytes (T-lymphocytes) in restenotic
tissue. This inflammatory response is characterized by the activation of
circulating leukocytes that express adhesion molecules on the cell
surface [2]. In this work we investigate stent-induced alterations in the
nanostructure, cytoskeleton and mechanical properties of circulating
lymphocytes in an effort to establish mechanical biomarkers to access
stent-induced inflammation in the adjacent vascular tissue.
implantation are the main causes of the initiation of thrombosis and
restenosis [1]. The mechanical properties of live cells can affect their
physical interactions with the surrounding extracellular matrix,
potentially influencing the process of mechanical signal transduction in
living tissues. Previous studies have described the infiltration of
inflammatory cells and immunocytes (T-lymphocytes) in restenotic
tissue. This inflammatory response is characterized by the activation of
circulating leukocytes that express adhesion molecules on the cell
surface [2]. In this work we investigate stent-induced alterations in the
nanostructure, cytoskeleton and mechanical properties of circulating
lymphocytes in an effort to establish mechanical biomarkers to access
stent-induced inflammation in the adjacent vascular tissue.
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