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Title: AM-FM texture image analysis in multiple sclerosis brain white matter lesions
Authors: Loizou, Christos P. 
Murray, Víctor 
Pattichis, Marios S. 
Pantziaris, Marios 
Seimenis, Ioannis 
Pattichis, Constantinos S. 
Major Field of Science: Engineering and Technology
Field Category: Medical Engineering
Keywords: Multiple sclerosis;AM-FM analysis;Brain white matter;Disease progression
Issue Date: May-2010
Source: 12th Mediterranean Conference on Medical and Biological Engineering and Computing, 2010, 27-30 May, Chalkidiki, Greece
Start page: 446
End page: 449
Journal: Mediterranean Conference on Medical and Biological Engineering and Computing 
Abstract: In this study we investigate the use of multiscale Amplitude Modulation-Frequency Modulation (AM-FM) methods for analyzing brain white matter lesions that are associated with multiple sclerosis MRI lesions imaged at 0 and 6-12 months. We use the instantaneous amplitude (IA) and the instantaneous frequency (IF) to assess disease progression. The IA and the IF were calculated in transverse sections of T2- weighted magnetic resonance (MR) images acquired from 38 symptomatic untreated subjects between the first and the second examination scan. The findings suggest that the high-, medium-, and low- frequency scale instantaneous amplitude and frequency can be used to differentiate between normal tissue and lesions at 0 and 6-12 months. Moreover, support vector machine (SVM) models gave satisfactory results for differentiating lesions at 0 months using the medium scale IA and IF components for expanded disability status scale (EDSS) <=2 and EDSS >2. Further work is needed with more subjects in validating the proposed AM-FM analysis. © 2010 International Federation for Medical and Biological Engineering.
ISBN: 978-3-642-13039-7
DOI: 10.1007/978-3-642-13039-7_112
Rights: © Springer
Type: Conference Papers
Affiliation : Intercollege 
University of New Mexico 
Cyprus Institute of Neurology and Genetics 
Ayios Therissos Medical Diagnostic Center 
University of Cyprus 
Appears in Collections:Δημοσιεύσεις σε συνέδρια /Conference papers or poster or presentation

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