Παρακαλώ χρησιμοποιήστε αυτό το αναγνωριστικό για να παραπέμψετε ή να δημιουργήσετε σύνδεσμο προς αυτό το τεκμήριο: https://hdl.handle.net/20.500.14279/23310
Τίτλος: Phantom for blood brain barrier opening using focused ultrasound and application in alzheimer's disease
Συγγραφείς: Alekou, Tereza 
Λέξεις-κλειδιά: Ultrasound;phantom;Blood brain barrier;Agar
Advisor: Damianou, Christakis A.
Ημερομηνία Έκδοσης: Ιου-2021
Department: Department of Electrical Engineering, Computer Engineering and Informatics
Faculty: Faculty of Engineering and Technology
Περίληψη: This doctoral dissertation is examining various challenges presented in the use of High Intensity Focused Ultrasound in brain applications. The study is separated into five different sub-studies in the area of agar phantoms and brain applications. The first study is concentrated on the design and creation of a suitable agar-based phantom to be used in HIFU application on the blood brain barrier opening. A model that currently is not available to researchers, whereas all experiments are performed on animal models. The second objective of this dissertation is the evaluation of the attenuation of agar-based phantoms with various concentrations. The next study includes the evaluation of the mechanical properties of agar-based phantoms such as the structure and the stiffness since these data will help in understanding the structure of the phantom according to its composition. The fourth study includes the evaluation of an alteration in the composition of an agar phantom with the use of a preservative and its effect on the life of the phantom in combination with the storing conditions. Finally, the last study examines an application for the reduction of amyloid β plaques in a rabbit model with the use of antibodies crossing the blood brain barrier.
URI: https://hdl.handle.net/20.500.14279/23310
Rights: Απαγορεύεται η δημοσίευση ή αναπαραγωγή, ηλεκτρονική ή άλλη χωρίς τη γραπτή συγκατάθεση του δημιουργού και κάτοχου των πνευματικών δικαιωμάτων.
Type: PhD Thesis
Affiliation: Cyprus University of Technology 
Εμφανίζεται στις συλλογές:Διδακτορικές Διατριβές/ PhD Theses

Αρχεία σε αυτό το τεκμήριο:
Αρχείο Περιγραφή ΜέγεθοςΜορφότυπος
PhD Dissertation.pdfFull text3.51 MBAdobe PDFΔείτε/ Ανοίξτε
CORE Recommender
Δείξε την πλήρη περιγραφή του τεκμηρίου

Page view(s) 5

468
Last Week
0
Last month
31
checked on 14 Μαρ 2025

Download(s) 5

309
checked on 14 Μαρ 2025

Google ScholarTM

Check


Αυτό το τεκμήριο προστατεύεται από άδεια Άδεια Creative Commons Creative Commons