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Title: The Effects of a Mediterranean Diet Intervention on Targeted Plasma Metabolic Biomarkers among US Firefighters: A Pilot Cluster-Randomized Trial
Authors: Sotos-Prieto, Mercedes 
Ruiz-Canela, Miguel 
Song, Yiqing 
Christophi, Costas A. 
Mofatt, Steven 
Rodriguez-Artalejo, Fernando 
Kales, Stefanos N. 
Major Field of Science: Medical and Health Sciences
Field Category: Health Sciences
Keywords: Mediterranean Diet;Biomarkers;Clinical trial;Lipoprotein composition;Metabolites
Issue Date: Dec-2020
Source: Nutrients, 2020, vol. 12, no. 12, articl. no. 3610
Volume: 12
Issue: 12
Journal: Nutrients 
Abstract: Metabolomics is improving the understanding of the mechanisms of the health effects of diet. Previous research has identified several metabolites associated with the Mediterranean Diet (MedDiet), but knowledge about longitudinal changes in metabolic biomarkers after a MedDiet intervention is scarce. A subsample of 48 firefighters from a cluster-randomized trial at Indianapolis fire stations was randomly selected for the metabolomics study at 12 months of follow up (time point 1), where Group 1 (n = 24) continued for another 6 months in a self-sustained MedDiet intervention, and Group 2 (n = 24), the control group at that time, started with an active MedDiet intervention for 6 months (time point 2). A total of 225 metabolites were assessed at the two time points by using a targeted NMR platform. The MedDiet score improved slightly but changes were non-significant (intervention: 24.2 vs. 26.0 points and control group: 26.1 vs. 26.5 points). The MedDiet intervention led to favorable changes in biomarkers related to lipid metabolism, including lower LDL-C, ApoB/ApoA1 ratio, remnant cholesterol, M-VLDL-CE; and higher HDL-C, and better lipoprotein composition. This MedDiet intervention induces only modest changes in adherence to the MedDiet and consequently in metabolic biomarkers. Further research should confirm these results based on larger study samples in workplace interventions with powerful study designs.
ISSN: 2072-6643
DOI: 10.3390/nu12123610
Rights: © by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Type: Article
Affiliation : Universidad Autónoma de Madrid 
Carlos III Health Institute 
Harvard University 
University of Navarra 
Carlos III Health Institute 
Indiana University 
Cyprus University of Technology 
National Institute for Public Safety Health, Indianapolis 
IMDEA-Food Institute 
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