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dc.contributor.authorStephanou, Pavlos S.-
dc.contributor.authorStefanou-
dc.date.accessioned2021-09-08T10:48:21Z-
dc.date.available2021-09-08T10:48:21Z-
dc.date.issued2021-07-27-
dc.identifier.citationRheologica Acta, 2021, vol. 60. no. 10, pp. 603 - 616en_US
dc.identifier.issn14351528-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/23002-
dc.description.abstractIn the past few decades, nanotechnology has been employed to provide breakthroughs in the diagnosis and treatment of several diseases using drug-carrying particles (DCPs). In such an endeavor, the optimal design of DCPs is paramount, which necessitates the use of an accurate and trustworthy constitutive model in computational fluid dynamics (CFD) simulators. We herein introduce a continuum model for elaborating on the rheological implications of adding particles in blood. The model is developed using non-equilibrium thermodynamics to guarantee thermodynamic admissibility. Red blood cells are modeled as deformed droplets with a constant volume that are able to aggregate, whereas particles are considered rigid spheroids. The model predictions are compared favorably against rheological data for both spherical and non-spherical particles immersed in non-aggregating blood. It is expected that the use of this model will allow for the testing of DCPs in virtual patients and for their tailor-design in treating various diseases.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofRheologica Actaen_US
dc.rights© The Author(s)en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBlooden_US
dc.subjectDifferential constitutive equationen_US
dc.subjectNon-equilibrium thermodynamicsen_US
dc.subjectNormal stressesen_US
dc.subjectParticleen_US
dc.subjectViscosityen_US
dc.titleElucidating the rheological implications of adding particles in blooden_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1007/s00397-021-01289-xen_US
dc.identifier.pmid34334825-
dc.identifier.scopus2-s2.0-85111276604-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85111276604-
dc.relation.issue10en_US
dc.relation.volume60en_US
cut.common.academicyear2020-2021en_US
dc.identifier.spage603en_US
dc.identifier.epage616en_US
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn1435-1528-
crisitem.journal.publisherSpringer Nature-
crisitem.author.deptDepartment of Chemical Engineering-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.orcid0000-0003-3182-0581-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
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