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Πεδίο DCΤιμήΓλώσσα
dc.contributor.authorGoulas, Vlasios-
dc.contributor.authorExarchou, Vassiliki-
dc.contributor.authorTroganis, Anastassios N.-
dc.contributor.authorPsomiadou, Eleni-
dc.contributor.authorFotsis, Theodore-
dc.contributor.authorBriasoulis, Evangelos C.-
dc.contributor.authorGerothanassis, Ioannis P.-
dc.date.accessioned2012-03-14T07:06:27Zen
dc.date.accessioned2013-05-16T06:25:40Z-
dc.date.accessioned2015-12-02T09:18:53Z-
dc.date.available2012-03-14T07:06:27Zen
dc.date.available2013-05-16T06:25:40Z-
dc.date.available2015-12-02T09:18:53Z-
dc.date.issued2009-05-
dc.identifier.citationMolecular Nutrition and Food Research, 2009, vol. 53, no. 5, pp. 600-608en_US
dc.identifier.issn16134133-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/2193-
dc.description.abstractOlive oil compounds is a dynamic research area because Mediterranean diet has been shown to protect against cardiovascular disease and cancer. Olive leaves, an easily available natural material of low cost, share possibly a similar wealth of health benefiting bioactive phytochemicals. In this work, we investigated the antioxidant potency and antiproliferative activity against cancer and endothelial cells of water and methanol olive leaves extracts and analyzed their content in phytochemicals using LC-MS and LC-UV-SPE-NMR hyphenated techniques. Olive-leaf crude extracts were found to inhibit cell proliferation of human breast adenocarcinoma (MCF-7), human urinary bladder carcinoma (T-24) and bovine brain capillary endothelial (BBCE). The dominant compound of the extracts was oleuropein; phenols and flavonoids were also identified. These phytochemicals demonstrated strong antioxidant potency and inhibited cancer and endothelial cell proliferation at low micromolar concentrations, which is significant considering their high abundance in fruits and vegetables. The antiproliferative activity of crude extracts and phytochemicals against the cell lines used in this study is demonstrated for the first time.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofMolecular Nutrition and Food Researchen_US
dc.rights© Wileyen_US
dc.subjectAngiogenesisen_US
dc.subjectCanceren_US
dc.subjectLC-SPE-NMRen_US
dc.subjectOleuropeinen_US
dc.subjectOlive leaf extracten_US
dc.titlePhytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cellsen_US
dc.typeArticleen_US
dc.affiliationUniversity of Ioanninaen
dc.collaborationUniversity of Ioanninaen_US
dc.collaborationHellenic Institute of Chemistryen_US
dc.subject.categoryAgriculture Forestry and Fisheriesen_US
dc.journalsSubscriptionen_US
dc.countryGreeceen_US
dc.subject.fieldAgricultural Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1002/mnfr.200800204en_US
dc.dept.handle123456789/54en
dc.relation.issue5en_US
dc.relation.volume53en_US
cut.common.academicyear2008-2009en_US
dc.identifier.spage600en_US
dc.identifier.epage608en_US
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn1613-4133-
crisitem.journal.publisherWiley-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.orcid0000-0001-7527-1559-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
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