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https://hdl.handle.net/20.500.14279/2033
Title: | Associations of childhood and adulthood height and the components of height with insulin-like growth factor (IGF) levels in adulthood: 65 year follow-up of the Boyd Orr cohort. | Authors: | Bray, Isabelle C. Gunnell, David J. Holly, Jeff M P Middleton, Nicos Smith, George Davey W Martin, Richard Michael |
metadata.dc.contributor.other: | Μίτλεττον, Νίκος | Major Field of Science: | Medical and Health Sciences | Issue Date: | 1-Apr-2006 | Source: | The Journal of Clinical Endocrinology & Metabolism, 2006, vol. 91, no. 4, pp. 1382-1389 | Volume: | 91 | Issue: | 4 | Start page: | 1382 | End page: | 1389 | Journal: | Journal of Clinical Endocrinology and Metabolism | Abstract: | Context: Taller individuals with longer legs have a higher risk of cancer but a lower risk of coronary heart disease. Objective: We investigated whether childhood height and its components are associated with the IGF system in adulthood. Design and Participants: We analyzed data from 429 participants of the Boyd Orr cohort, for whom height measured in childhood (mean age, 7.4 yr) in 1937–1939 could be related to levels of IGF-I, IGF-II, IGF binding protein (IGFBP)-2, and IGFBP-3 in adulthood (mean age, 71.1 yr). In 385 participants, measured height in adulthood could be related to IGF levels. Results: In fully adjusted models (controlling for age, sex, socioeconomic factors, lifestyle, and body mass index), childhood height and its components were not associated with adult circulating IGF-I, IGF-II, or IGFBP-2 levels. IGFBP-3 was 85.5 ng/ml higher (95% confidence interval, 11.6 to 182.5; P 0.08) per SD increase in childhood trunk length and 83.6 ng/ml lower (95% confidence interval, 10.3 to 177.5; P 0.08) per SD increase in childhood leg/trunk ratio. Height in adulthood was not associated with IGF-I, IGF-II, or IGFBP-3 and was inversely associated with IGFBP-2 (P 0.05) after additionally controlling for childhood height. Conclusion: There was no evidence that associations of childhood height with cancer and coronary heart disease risk are mediated by IGF-I in adulthood. The anthropometric associations with IGFBP-2 and IGFBP-3 could be chance findings but warrant additional investigation. IGF levels in childhood may be more important determinants of long-term disease risk than adult levels. (J Clin Endocrinol Metab 91: 1382–1389, 2006) | URI: | https://hdl.handle.net/20.500.14279/2033 | DOI: | 10.1210/jc.2005-1722 | Rights: | © The Endocrine Society | Type: | Article | Affiliation: | University of Bristol | Affiliation : | University of Bristol | Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
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Bray et al Associations of childhood and adulthood height J Clin Endocr.pdf | 151.51 kB | Adobe PDF | View/Open |
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