Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/2033
Title: | Associations of childhood and adulthood height and the components of height with insulin-like growth factor (IGF) levels in adulthood: 65 year follow-up of the Boyd Orr cohort. | Authors: | Bray, Isabelle C. Gunnell, David J. Holly, Jeff M P Middleton, Nicos Smith, George Davey W Martin, Richard Michael |
metadata.dc.contributor.other: | Μίτλεττον, Νίκος | Major Field of Science: | Medical and Health Sciences | Issue Date: | 1-Apr-2006 | Source: | The Journal of Clinical Endocrinology & Metabolism, 2006, vol. 91, no. 4, pp. 1382-1389 | Volume: | 91 | Issue: | 4 | Start page: | 1382 | End page: | 1389 | Journal: | Journal of Clinical Endocrinology and Metabolism | Abstract: | Context: Taller individuals with longer legs have a higher risk of cancer but a lower risk of coronary heart disease. Objective: We investigated whether childhood height and its components are associated with the IGF system in adulthood. Design and Participants: We analyzed data from 429 participants of the Boyd Orr cohort, for whom height measured in childhood (mean age, 7.4 yr) in 1937–1939 could be related to levels of IGF-I, IGF-II, IGF binding protein (IGFBP)-2, and IGFBP-3 in adulthood (mean age, 71.1 yr). In 385 participants, measured height in adulthood could be related to IGF levels. Results: In fully adjusted models (controlling for age, sex, socioeconomic factors, lifestyle, and body mass index), childhood height and its components were not associated with adult circulating IGF-I, IGF-II, or IGFBP-2 levels. IGFBP-3 was 85.5 ng/ml higher (95% confidence interval, 11.6 to 182.5; P 0.08) per SD increase in childhood trunk length and 83.6 ng/ml lower (95% confidence interval, 10.3 to 177.5; P 0.08) per SD increase in childhood leg/trunk ratio. Height in adulthood was not associated with IGF-I, IGF-II, or IGFBP-3 and was inversely associated with IGFBP-2 (P 0.05) after additionally controlling for childhood height. Conclusion: There was no evidence that associations of childhood height with cancer and coronary heart disease risk are mediated by IGF-I in adulthood. The anthropometric associations with IGFBP-2 and IGFBP-3 could be chance findings but warrant additional investigation. IGF levels in childhood may be more important determinants of long-term disease risk than adult levels. (J Clin Endocrinol Metab 91: 1382–1389, 2006) | URI: | https://hdl.handle.net/20.500.14279/2033 | DOI: | 10.1210/jc.2005-1722 | Rights: | © The Endocrine Society | Type: | Article | Affiliation: | University of Bristol | Affiliation : | University of Bristol | Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Bray et al Associations of childhood and adulthood height J Clin Endocr.pdf | 151.51 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
50
24
checked on Nov 9, 2023
WEB OF SCIENCETM
Citations
50
23
Last Week
0
0
Last month
0
0
checked on Oct 29, 2023
Page view(s) 50
458
Last Week
2
2
Last month
2
2
checked on Nov 6, 2024
Download(s) 50
219
checked on Nov 6, 2024
Google ScholarTM
Check
Altmetric
Items in KTISIS are protected by copyright, with all rights reserved, unless otherwise indicated.