Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/19440
DC FieldValueLanguage
dc.contributor.authorUvnäs-Moberg, Kerstin-
dc.contributor.authorEkström-Bergström, Anette-
dc.contributor.authorBuckley, Sarah J.-
dc.contributor.authorMassarotti, Claudia-
dc.contributor.authorPajalić, Zada-
dc.contributor.authorLuegmair, Karolina-
dc.contributor.authorKotłowska, Alicia-
dc.contributor.authorLengler, Luise-
dc.contributor.authorOlza, Ibone-
dc.contributor.authorGrylka-Baeschlin, Susanne-
dc.contributor.authorLeahy-Warren, Patricia-
dc.contributor.authorHadjigeorgiou, Eleni-
dc.contributor.authorVillarmea, Stella-
dc.contributor.authorDencker, Anna-
dc.date.accessioned2020-11-19T09:07:33Z-
dc.date.available2020-11-19T09:07:33Z-
dc.date.issued2020-08-
dc.identifier.citationPLoS ONE, 2020, vol. 15, no. 8, articl. no. e0235806en_US
dc.identifier.issn19326203-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/19440-
dc.description.abstractIntroduction Oxytocin is a key hormone in breastfeeding. No recent review on plasma levels of oxytocin in response to breastfeeding is available. Materials and methods Systematic literature searches on breastfeeding induced oxytocin levels were conducted 2017 and 2019 in PubMed, Scopus, CINAHL, and PsycINFO. Data on oxytocin linked effects and effects of medical interventions were included if available. Results We found 29 articles that met the inclusion criteria. All studies had an exploratory design and included 601 women. Data were extracted from the articles and summarised in tables. Breastfeeding induced an immediate and short lasting (20 minutes) release of oxytocin. The release was pulsatile early postpartum (5 pulses/10 minutes) and coalesced into a more protracted rise as lactation proceeded. Oxytocin levels were higher in multiparous versus primiparous women. The number of oxytocin pulses during early breastfeeding was associated with greater milk yield and longer duration of lactation and was reduced by stress. Breastfeeding-induced oxytocin release was associated with elevated prolactin levels; lowered ACTH and cortisol (stress hormones) and somatostatin (a gastrointestinal hormone) levels; enhanced sociability; and reduced anxiety, suggesting that oxytocin induces physiological and psychological adaptations in the mother. Mechanical breast pumping, but not bottle-feeding was associated with oxytocin and prolactin release and decreased stress levels. Emergency caesarean section reduced oxytocin and prolactin release in response to breastfeeding and also maternal mental adaptations. Epidural analgesia reduced prolactin and mental adaptation, whereas infusions of synthetic oxytocin increased prolactin and mental adaptation. Oxytocin infusion also restored negative effects induced by caesarean section and epidural analgesia. Conclusions Oxytocin is released in response to breastfeeding to cause milk ejection, and to induce physiological changes to promote milk production and psychological adaptations to facilitate motherhood. Stress and medical interventions during birth may influence these effects and thereby adversely affect the initiation of breastfeeding.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofPLoS ONEen_US
dc.rights© 2020 Uvna¨s-Moberg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCorticotropinen_US
dc.subjectHydrocortisoneen_US
dc.subjectOxytocinen_US
dc.subjectSomatostatinen_US
dc.subjectProlactinen_US
dc.subjectBreast feedingen_US
dc.titleMaternal plasma levels of oxytocin during breastfeeding-A systematic reviewen_US
dc.typeArticleen_US
dc.collaborationSwedish University of Agricultural Sciencesen_US
dc.collaborationUniversity of Westen_US
dc.collaborationUniversity of Queenslanden_US
dc.collaborationUniversity of Genoaen_US
dc.collaborationIRCCS-Azienda Ospedaliera Universitaria San Martinoen_US
dc.collaborationVID Specialized Universityen_US
dc.collaborationBerufs Bildung Zentrum Gesundheit Ingolstadten_US
dc.collaborationMedical University of Gdansken_US
dc.collaborationFreiburg University Medical Centeren_US
dc.collaborationUniversity of Alcaláen_US
dc.collaborationZurich University of Applied Sciencesen_US
dc.collaborationUniversity College Corken_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationUniversity of Oxforden_US
dc.collaborationUniversity of Gothenburgen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsOpen Accessen_US
dc.countrySwedenen_US
dc.countryAustraliaen_US
dc.countryItalyen_US
dc.countryNorwayen_US
dc.countryGermanyen_US
dc.countryPolanden_US
dc.countrySpainen_US
dc.countrySwitzerlanden_US
dc.countryIrelanden_US
dc.countryCyprusen_US
dc.countryUnited Kingdomen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1371/journal.pone.0235806en_US
dc.identifier.pmid32756565-
dc.relation.issue8en_US
dc.relation.volume15en_US
cut.common.academicyear2019-2020en_US
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn1932-6203-
crisitem.journal.publisherPloS-
crisitem.author.deptDepartment of Nursing-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0002-5834-4207-
crisitem.author.parentorgFaculty of Health Sciences-
Appears in Collections:Άρθρα/Articles
Files in This Item:
File Description SizeFormat
journal.pone.0235806.pdfFulltext1.29 MBAdobe PDFView/Open
CORE Recommender
Show simple item record

SCOPUSTM   
Citations

101
checked on Mar 14, 2024

WEB OF SCIENCETM
Citations

78
Last Week
0
Last month
5
checked on Oct 29, 2023

Page view(s)

352
Last Week
1
Last month
32
checked on Mar 14, 2025

Download(s)

169
checked on Mar 14, 2025

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons