Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/19206
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lan, Fan Yun | - |
dc.contributor.author | Filler, Robert | - |
dc.contributor.author | Mathew, Soni | - |
dc.contributor.author | Buley, Jane | - |
dc.contributor.author | Iliaki, Eirini | - |
dc.contributor.author | Bruno-Murtha, Lou Ann | - |
dc.contributor.author | Osgood, Rebecca | - |
dc.contributor.author | Osgood, Rebecca | - |
dc.contributor.author | Christophi, Costas A. | - |
dc.contributor.author | Fernandez-Montero, Alejandro | - |
dc.contributor.author | Kales, Stefanos N. | - |
dc.date.accessioned | 2020-10-20T06:32:30Z | - |
dc.date.available | 2020-10-20T06:32:30Z | - |
dc.date.issued | 2020-06-01 | - |
dc.identifier.citation | PLoS ONE, 2020, vol. 15, no. 6, article no. e0235460 | en_US |
dc.identifier.issn | 19326203 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/19206 | - |
dc.description.abstract | Background Coronavirus 2019 disease (COVID-19) is caused by the virus SARS-CoV-2, transmissible both person-to-person and from contaminated surfaces. Early COVID-19 detection among healthcare workers (HCWs) is crucial for protecting patients and the healthcare workforce. Because of limited testing capacity, symptom-based screening may prioritize testing and increase diagnostic accuracy. Methods and findings We performed a retrospective study of HCWs undergoing both COVID-19 telephonic symptom screening and nasopharyngeal SARS-CoV-2 assays during the period, March 9.April 15, 2020. HCWs with negative assays but progressive symptoms were re-tested for SARSCoV- 2. Among 592 HCWs tested, 83 (14%) had an initial positive SARS-CoV-2 assay. Fiftynine of 61 HCWs (97%) who were asymptomatic or reported only sore throat/nasal congestion had negative SARS-CoV-2 assays (P = 0.006). HCWs reporting three or more symptoms had an increased multivariate-adjusted odds of having positive assays, 1.95 (95% CI: 1.10.3.64), which increased to 2.61 (95% CI: 1.50.4.45) for six or more symptoms. The multivariate-adjusted odds of a positive assay were also increased for HCWs reporting fever and a measured temperature . 37.5°C (3.49 (95% CI: 1.95.6.21)), and those with myalgias (1.83 (95% CI: 1.04.3.23)). Anosmia/ageusia (i.e. loss of smell/loss of taste) was reported less frequently (16%) than other symptoms by HCWs with positive assays, but was associated with more than a seven-fold multivariate-adjusted odds of a positive test: OR = 7.21 (95% CI: 2.95.17.67). Of 509 HCWs with initial negative SARS-CoV-2 assays, nine had symptom progression and positive re-tests, yielding an estimated negative predictive value of 98.2% (95% CI: 96.8-99.0%) for the exclusion of clinically relevant COVID-19. Conclusions Symptom and temperature reports are useful screening tools for predicting SARS-CoV-2 assay results in HCWs. Anosmia/ageusia, fever, and myalgia were the strongest independent predictors of positive assays. The absence of symptoms or symptoms limited to nasal congestion/sore throat were associated with negative assays. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.rights | © Lan et al. | en_US |
dc.subject | Adult | en_US |
dc.subject | Ageusia | en_US |
dc.subject | Asymptomatic Infections | en_US |
dc.subject | Betacoronavirus | en_US |
dc.subject | Body Temperature | en_US |
dc.subject | Coronavirus Infections | en_US |
dc.subject | Female | en_US |
dc.subject | Fever | en_US |
dc.subject | Health Personnel | en_US |
dc.subject | Humans | en_US |
dc.subject | Logistic Models | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Multivariate Analysis | en_US |
dc.subject | Myalgia | en_US |
dc.subject | Nasopharynx | en_US |
dc.subject | Olfaction Disorders | en_US |
dc.subject | Pandemics | en_US |
dc.subject | Pharyngitis | en_US |
dc.subject | Pneumonia, Viral | en_US |
dc.subject | Polymerase Chain Reaction | en_US |
dc.subject | Principal Component Analysis | en_US |
dc.subject | Retrospective Studies | en_US |
dc.title | COVID-19 symptoms predictive of healthcare workers' SARS-CoV-2 PCR results | en_US |
dc.type | Article | en_US |
dc.collaboration | National Cheng Kung University | en_US |
dc.collaboration | Harvard University | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | University of Navarra | en_US |
dc.subject.category | Health Sciences | en_US |
dc.journals | Open Access | en_US |
dc.country | United States | en_US |
dc.country | Taiwan | en_US |
dc.country | Cyprus | en_US |
dc.country | Spain | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1371/journal.pone.0235460 | en_US |
dc.identifier.pmid | 32589687 | en |
dc.identifier.scopus | 2-s2.0-85087320333 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85087320333 | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.contributor.orcid | #NODATA# | en |
dc.relation.issue | 6 | en_US |
dc.relation.volume | 15 | en_US |
cut.common.academicyear | 2019-2020 | en_US |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | open | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0003-0503-1538 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.journal.journalissn | 1932-6203 | - |
crisitem.journal.publisher | PloS | - |
Appears in Collections: | Άρθρα/Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
COVID-19 symptoms.pdf | Open Access | 572.23 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
108
checked on Feb 1, 2024
WEB OF SCIENCETM
Citations
91
Last Week
0
0
Last month
2
2
checked on Oct 29, 2023
Page view(s) 50
323
Last Week
0
0
Last month
8
8
checked on Aug 28, 2024
Download(s)
168
checked on Aug 28, 2024
Google ScholarTM
Check
Altmetric
Items in KTISIS are protected by copyright, with all rights reserved, unless otherwise indicated.