Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/18592
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Charisiadis, Pantelis | - |
dc.contributor.author | Delplancke, Thibaut | - |
dc.contributor.author | Makris, Konstantinos C. | - |
dc.date.accessioned | 2020-07-28T09:59:32Z | - |
dc.date.available | 2020-07-28T09:59:32Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | Analytical and Bioanalytical Chemistry, 2019, vol. 411, no. 20, pp. 5013–5021 | en_US |
dc.identifier.issn | 16182650 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/18592 | - |
dc.description.abstract | Neonicotinoids (NEOs) and synthetic pyrethroids (PYRs) are active ingredients of commercial pesticides and/or insecticides with extensive indoor and outdoor applications, worldwide. Improved exposure metrics are warranted for NEOs and PYRs, if we are to better understand their human health effects. A cohort-friendly protocol for determining non-specific biomarkers of exposure to NEOs and PYRs, e.g. 6-chloronicotinic acid (6-CN) and 3-phenoxybenzoic acid (3-PBA), respectively, in human urine voids was proposed. A series of optimization experiments were conducted to validate the bioanalytical protocol using gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ-MS/MS) in MRM mode. The method reached low detection limits for both analytes (0.075 μg L−1 for 6-CN and 0.050 μg L−1 for 3-PBA) in a short preparation and analysis time. The method used small initial urine sample volume (2 mL), short extraction time (≈ 240 min for the batches of 32 samples) and instrumental analysis time (≈ 14 min) for both pesticide metabolites in a single run. This protocol could facilitate the assessment of population exposure metrics for these pesticides and their inclusion in health risk assessment. [Figure not available: see fulltext.]. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Analytical and Bioanalytical Chemistry | en_US |
dc.rights | © Springer Nature | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | 3-Phenoxybenzoic acid | en_US |
dc.subject | 6-Chloronicotinic acid | en_US |
dc.subject | Cohorts | en_US |
dc.subject | Exposure | en_US |
dc.subject | Metabolites | en_US |
dc.subject | Neonicotinoids | en_US |
dc.subject | Pesticides | en_US |
dc.subject | Pyrethroids | en_US |
dc.title | Cohort-friendly protocol for the determination of two urinary biomarkers of exposure to pyrethroids and neonicotinoids using gas chromatography-triple quadrupole mass spectrometry | en_US |
dc.type | Article | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.subject.category | Basic Medicine | en_US |
dc.journals | Subscription | en_US |
dc.country | Cyprus | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1007/s00216-019-01925-9 | en_US |
dc.identifier.pmid | 31222408 | - |
dc.identifier.scopus | 2-s2.0-85068173724 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85068173724 | - |
dc.relation.issue | 20 | en_US |
dc.relation.volume | 411 | en_US |
cut.common.academicyear | 2019-2020 | en_US |
dc.identifier.spage | 5013 | en_US |
dc.identifier.epage | 5021 | en_US |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
crisitem.journal.journalissn | 1618-2650 | - |
crisitem.journal.publisher | Springer Nature | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0001-7260-192X | - |
crisitem.author.orcid | 0000-0001-5251-8619 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Appears in Collections: | Άρθρα/Articles |
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