Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/18513
Title: An energy-rate based blood viscosity model incorporating aggregate network dynamics
Authors: Kaliviotis, Efstathios 
Yianneskis, Michael 
Major Field of Science: Engineering and Technology
Field Category: Electrical Engineering - Electronic Engineering - Information Engineering
Keywords: Energy balance;Inter-cellular forces;Network formation;RBC aggregation
Issue Date: 2009
Source: Biorheology, vol. 46, iss. 6, 2009, pp. 487-508
Volume: 46
Issue: 6
Start page: 487
End page: 508
Journal: Biorheology 
Abstract: Existing time-dependent blood viscosity models that involve aggregation dynamics are mainly based on structural variables and/or viscoelastic models in order to describe the bulk mechanical properties of the fluid, but the implications of important characteristics of blood microstructure, such as the time- and flow-dependent characteristics of the red blood cell network developed due to aggregation at low shear rates, have not been thoroughly investigated. In this paper a time-dependent blood viscosity model is developed based on an energy-rate model previously proposed (Skalak et al., Biophys. J. 35 (1977), 771-781), which describes the total work needed to overcome the various forces developed between aggregated cells, including the adhesive, elastic and dissipative forces. Novel formulations of the forces acting on the fluid are developed and implemented in a volume-averaged version of the energy-rate model. The calculation of the viscosity is based on the relationship between the rate of energy changes and shear stress per unit volume of the fluid. The results show that network characteristics may significantly influence the viscosity blood at low shear rates and exhibit good agreement with experimental observations.
URI: https://hdl.handle.net/20.500.14279/18513
ISSN: 0006355X
DOI: 10.3233/BIR-2009-0555
Rights: © IOS
Type: Article
Affiliation : King's College London 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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