Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/16457
DC FieldValueLanguage
dc.contributor.authorAntoniou, Chrystalla-
dc.contributor.authorXenofontos, Rafaella-
dc.contributor.authorChatzimichail, Giannis-
dc.contributor.authorChristou, Anastasis-
dc.contributor.authorKashfi, Khosrow-
dc.contributor.authorFotopoulos, Vasileios-
dc.date.accessioned2020-02-19T12:20:54Z-
dc.date.available2020-02-19T12:20:54Z-
dc.date.issued2020-01-10-
dc.identifier.citationBiomolecules, 2020, vol. 10, no. 1, articl. no. 120en_US
dc.identifier.issn2218-273X-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/16457-
dc.description.abstractLand plants are continuously exposed to multiple abiotic stress factors like drought, heat, and salinity. Nitric oxide (NO) and hydrogen sulfide (H2S) are two well-examined signaling molecules that act as priming agents, regulating the response of plants to stressful conditions. Several chemical donors exist that provide plants with NO and H2S separately. NOSH is a remarkable novel donor as it can donate NO and H2S simultaneously to plants, while NOSH-aspirin additionally provides the pharmaceutical molecule acetylsalicylic acid. The current study aimed to investigate the potential synergistic effect of these molecules in drought-stressed Medicago sativa L. plants by following a pharmacological approach. Plants were initially pre-treated with both donors (NOSH and NOSH-aspirin) via foliar spraying, and were then subsequently exposed to a moderate water deficit while NO and H2S inhibitors (cPTIO and HA, respectively) were also employed. Phenotypic and physiological data showed that pre-treatment with NOSH synthetic compounds induced acclimation to subsequent drought stress and improved the recovery following rewatering. This was accompanied by modified reactive-oxygen and nitrogen-species signaling and metabolism, as well as attenuation of cellular damage, as evidenced by altered lipid peroxidation and proline accumulation levels. Furthermore, real-time RT-qPCR analysis revealed the differential regulation of multiple defense-related transcripts, including antioxidant enzymes. Overall, the present study proposed a novel role for NOSH compounds as efficient plant priming agents against environmental constraints through the coordinated regulation of multiple defense components, thus opening new horizons in the field of chemical priming research toward the use of target-selected compounds for stress tolerance enhancement.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofBiomoleculesen_US
dc.rights© by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectNitric oxideen_US
dc.subjectAlfalfaen_US
dc.subjectAntioxidantsen_US
dc.subjectAspirinen_US
dc.subjectDroughten_US
dc.subjectHydrogen sulfideen_US
dc.subjectProlineen_US
dc.subjectProlineen_US
dc.subjectPrimingen_US
dc.titleExploring the Potential of Nitric Oxide and Hydrogen Sulfide (NOSH)-Releasing Synthetic Compounds as Novel Priming Agents against Drought Stress in Medicago sativa Plantsen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationAgricultural Research Institute of Cyprusen_US
dc.collaborationCity University of New York School of Medicineen_US
dc.subject.categoryAgricultural Biotechnologyen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.countryUnited Statesen_US
dc.subject.fieldAgricultural Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.3390/biom10010120en_US
dc.identifier.pmid31936819-
dc.identifier.scopus2-s2.0-85077843667-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85077843667-
dc.relation.issue1en_US
dc.relation.volume10en_US
cut.common.academicyear2019-2020en_US
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
item.grantfulltextopen-
crisitem.journal.journalissn2218-273X-
crisitem.journal.publisherMDPI-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.orcid0000-0003-1205-2070-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
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