Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/1589
DC FieldValueLanguage
dc.contributor.authorRunnels, Judith M.-
dc.contributor.authorCarlson, Alicia L.-
dc.contributor.authorPitsillides, Costas-
dc.contributor.authorThompson, Brian D.-
dc.contributor.authorWu, Juwell-
dc.contributor.authorSpencer, Joel A.-
dc.contributor.authorKohler, John-
dc.contributor.authorAzab, Abdel Kareem-
dc.contributor.authorMoreau, Anne Sophie-
dc.contributor.authorRodig, Scott-
dc.contributor.authorKung, Andrew L.-
dc.contributor.authorAnderson, Kenneth Carl-
dc.contributor.authorGhobrial, Irène M.-
dc.contributor.authorLin, Charles P.-
dc.date.accessioned2013-02-22T13:35:27Zen
dc.date.accessioned2013-05-17T05:22:29Z-
dc.date.accessioned2015-12-02T10:01:08Z-
dc.date.available2013-02-22T13:35:27Zen
dc.date.available2013-05-17T05:22:29Z-
dc.date.available2015-12-02T10:01:08Z-
dc.date.issued2011-01-
dc.identifier.citationJournal of biomedical optics, 2011, vol. 16, no. 1en_US
dc.identifier.issn15602281-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/1589-
dc.description.abstractMultiple myeloma (MM), the second most common hematological malignancy, initiates from a single site and spreads via circulation to multiple sites in the bone marrow (BM). Methods to track MM cells both in the BM and circulation would be useful for developing new therapeutic strategies to target MM cell spread. We describe the use of complementary optical techniques to track human MM cells expressing both bioluminescent and fluorescent reporters in a mouse xenograft model. Long-term tumor growth and response to therapy are monitored using bioluminescence imaging (BLI), while numbers of circulating tumor cells are detected by in-vivo flow cytometry. Intravital microscopy is used to detect early seeding of MM cells to the BM, as well as residual cancer cells that remain in the BM after the bulk of the tumor is eradicated following drug treatment. Thus, intravital microscopy provides a powerful, albeit invasive, means to study cellular processes in vivo at the very early stage of the disease process and at the very late stage of therapeutic intervention when the tumor burden is too small to be detected by other imaging methodsen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Biomedical Opticsen_US
dc.rights© SPIEen_US
dc.subjectMultiple myelomaen_US
dc.subjectBioluminescenceen_US
dc.subjectConfocal microscopyen_US
dc.subjectIntravital imagingen_US
dc.subjectIn vivo cell trackingen_US
dc.subjectIn vivo flow cytometryen_US
dc.titleOptical techniques for tracking multiple myeloma engraftment, growth, and response to therapyen_US
dc.typeArticleen_US
dc.affiliationMassachusetts General Hospitalen
dc.collaborationMassachusetts General Hospitalen_US
dc.collaborationDana-Farber Cancer Instituteen_US
dc.collaborationBrigham and Women's Hospitalen_US
dc.collaborationDana-Farber Cancer Instituteen_US
dc.collaborationBoston Children’s Hospitalen_US
dc.subject.categoryENGINEERING AND TECHNOLOGYen_US
dc.journalsSubscriptionen_US
dc.countryUnited Statesen_US
dc.subject.fieldEngineering and Technologyen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1117/1.3520571en_US
dc.identifier.pmid21280893-
dc.dept.handle123456789/54en
dc.relation.issue1en_US
dc.relation.volume16en_US
cut.common.academicyear2010-2011en_US
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.journal.journalissn1083-3668-
crisitem.journal.publisherSPIE-
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