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https://hdl.handle.net/20.500.14279/1426
Πεδίο DC | Τιμή | Γλώσσα |
---|---|---|
dc.contributor.author | Chakraverty, Ronjon K. | - |
dc.contributor.author | Côté, Daniel | - |
dc.contributor.author | Pitsillides, Costas | - |
dc.date.accessioned | 2013-03-04T11:07:54Z | en |
dc.date.accessioned | 2013-05-17T05:22:55Z | - |
dc.date.accessioned | 2015-12-02T10:12:53Z | - |
dc.date.available | 2013-03-04T11:07:54Z | en |
dc.date.available | 2013-05-17T05:22:55Z | - |
dc.date.available | 2015-12-02T10:12:53Z | - |
dc.date.issued | 2006-07-31 | - |
dc.identifier.citation | Journal of Experimental Medicine, 2006,vol. 203, no. 8, pp. 2021-2031 | en_US |
dc.identifier.issn | 15409538 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/1426 | - |
dc.description.abstract | Transfer of T cells to freshly irradiated allogeneic recipients leads to their rapid recruitment to nonlymphoid tissues, where they induce graft-versus-host disease (GVHD). In contrast, when donor T cells are transferred to established mixed chimeras (MCs), GVHD is not induced despite a robust graft-versus-host (GVH) reaction that eliminates normal and malignant host hematopoietic cells. We demonstrate here that donor GVH-reactive T cells transferred to MCs or freshly irradiated mice undergo similar expansion and activation, with similar up-regulation of homing molecules required for entry to nonlymphoid tissues. Using dynamic two-photon in vivo microscopy, we show that these activated T cells do not enter GVHD target tissues in established MCs, contrary to the dogma that activated T cells inevitably traffic to nonlymphoid tissues. Instead, we show that the presence of inflammation within a nonlymphoid tissue is a prerequisite for the trafficking of activated T cells to that site. Our studies help to explain the paradox whereby GVH-reactive T cells can mediate graft-versus-leukemia responses without inducing GVHD in established MCs | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Experimental Medicine | en_US |
dc.rights | © The Rockefeller University Press | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | T cells | en_US |
dc.subject | Mice | en_US |
dc.subject | Animal experimentation | en_US |
dc.subject | Animal tissue | en_US |
dc.subject | graft versus host reaction | en_US |
dc.subject | Graft versus host disease | en_US |
dc.subject | Inflammation | en_US |
dc.title | An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues | en_US |
dc.type | Article | en_US |
dc.affiliation | Massachusetts General Hospital | en |
dc.collaboration | Wellman Center for Photomedicine | en_US |
dc.collaboration | Transplantation Biology Research Center | en_US |
dc.subject.category | Basic Medicine | en_US |
dc.journals | Subscription | en_US |
dc.country | Cyprus | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1084/jem.20060376 | en_US |
dc.identifier.pmid | 16880259 | - |
dc.dept.handle | 123456789/54 | en |
dc.relation.issue | 8 | en_US |
dc.relation.volume | 203 | en_US |
cut.common.academicyear | 2006-2007 | en_US |
dc.identifier.spage | 2021 | en_US |
dc.identifier.epage | 2031 | en_US |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.journal.journalissn | 1540-9538 | - |
crisitem.journal.publisher | Rockefeller University Press | - |
crisitem.author.dept | Department of Mechanical Engineering and Materials Science and Engineering | - |
crisitem.author.faculty | Faculty of Engineering and Technology | - |
crisitem.author.parentorg | Faculty of Engineering and Technology | - |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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