Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/13883
DC FieldValueLanguage
dc.contributor.authorDamianou, Christakis A.-
dc.contributor.authorHadjisavvas, V.-
dc.contributor.authorIoannides, K.-
dc.date.accessioned2019-05-31T08:38:53Z-
dc.date.available2019-05-31T08:38:53Z-
dc.date.issued2011-10-13-
dc.identifier.citation10th International Symposium on Therapeutic Ultrasound, ISTU 2010; Tokyo; Japan; 9 June 2010 through 12 June 2010en_US
dc.identifier.isbn978-073540917-0-
dc.identifier.issn0094-243X-
dc.description.abstractIn this paper an MR-guided focused pulsed ultrasound system for the treatment of stroke using thrombolytic drugs in a model in vitro is presented. A single element spherically focused transducer of 5 cm diameter; focusing at 10 cm and operating at 0.5 MHz or 1 MHz was used. The transducer was mounted in an MR compatible robot. The artery was modelled using a silicone tube. Tissue was modelled using polyaclylimide gel. Coagulated blood was used to model thrombus. A thermocouple was placed in the thrombus in order to measure the thrombus temperature. The effect of power, beam, and frequency was investigated. The goal was to maintain a temperature increase of less than 1°C during the application of pulse ultrasound (called safe temperature). With the application of ultrasound alone there was no notable destruction of the thrombus. With the combination of ultrasound and thrombolytic drugs destruction occurred after 60 mins of pulse exposure (PRF=1 s, duty factor=10 %, and with thrombus placed at 1 cm deep in the tissue). This simple in vitro model was proven very successful for evaluating MRgFUS as a modality for treating stroke. In the future we plan to apply this treatment protocol in live animals and humans. © 2011 American Institute of Physics.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.subjectMRIen_US
dc.subjectPulse ultrasounden_US
dc.subjectThrombolytic drugsen_US
dc.titleApplication of MR-guided focused pulsed ultrasound for destroying clots in vitro using thrombolytic drugsen_US
dc.typeConference Papersen_US
dc.collaborationFrederick Universityen_US
dc.collaborationCity University Londonen_US
dc.collaborationMedsonic Ltden_US
dc.subject.categoryElectrical Engineering - Electronic Engineering - Information Engineeringen_US
dc.countryCyprusen_US
dc.countryUnited Kingdomen_US
dc.subject.fieldEngineering and Technologyen_US
dc.publicationPeer Revieweden_US
dc.relation.conferenceAIP Conferenceen_US
dc.identifier.doi10.1063/1.3607893en_US
dc.identifier.scopus2-s2.0-80053640493en
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/80053640493en
dc.contributor.orcid#NODATA#en
dc.contributor.orcid#NODATA#en
dc.contributor.orcid#NODATA#en
dc.relation.volume1359en_US
cut.common.academicyear2011-2012en_US
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_c94f-
item.openairetypeconferenceObject-
item.fulltextNo Fulltext-
crisitem.author.deptDepartment of Electrical Engineering, Computer Engineering and Informatics-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.orcid0000-0003-0424-2851-
crisitem.author.parentorgFaculty of Engineering and Technology-
Appears in Collections:Δημοσιεύσεις σε συνέδρια /Conference papers or poster or presentation
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