Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/13616
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Giannakou, Konstantinos | - |
dc.contributor.author | Evangelou, Evangelos | - |
dc.contributor.author | Yiallouros, Panayiotis K. | - |
dc.contributor.author | Christophi, Costas A. | - |
dc.contributor.author | Middleton, Nicos | - |
dc.contributor.author | Papatheodorou, Evgenia | - |
dc.contributor.author | Papatheodorou, Stefania | - |
dc.date.accessioned | 2019-05-13T19:57:33Z | - |
dc.date.available | 2019-05-13T19:57:33Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.citation | PLoS ONE, 2019, vol. 14, no. 4 | en_US |
dc.identifier.issn | 19326203 | - |
dc.description.abstract | Background/Objective Gestational diabetes mellitus (GDM) is a common pregnancy complication, with complex disease mechanisms, and several risk factors may contribute to its onset. We performed an umbrella review to summarize the evidence from meta-analyses of observational studies on risk factors associated with GDM, evaluate whether there are indications of biases in this literature and identify which of the previously reported associations are supported by convincing evidence. Methods We searched PubMed and ISI Web of Science from inception to December 2018 to identify meta-analyses examining associations between putative risk factors for GDM. For each meta-analysis we estimated the summary effect size, the 95% confidence interval, the 95% prediction interval, the between-study heterogeneity, evidence of small-study effects, and evidence of excess-significance bias. Results Thirty eligible meta-analyses were identified, providing data on 61 associations. Fifty (82%) associations had nominally statistically significant findings (P<0.05), while only 15 (25%) were significant at P<10 -6 under the random-effects model. Only four risk factors presented convincing evidence:, low vs. normal BMI (cohort studies), BMI ∼30-35 kg/m2 vs. normal BMI, BMI >35 kg/m2 vs. normal BMI, and hypothyroidism. Conclusions The compilation of results from synthesis of observational studies suggests that increased BMI and hypothyroidism show the strongest consistent evidence for an association with GDM. Diet and lifestyle modifications in pregnancy should be tested in large randomized trials. Our findings suggest that women with known thyroid disease may be offered screening for GDM earlier in pregnancy. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.rights | © Giannakou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.subject | Evidence based medicine | en_US |
dc.subject | Pregnancy diabetes mellitus | en_US |
dc.subject | Pregnancy diabetes mellitus | en_US |
dc.subject | Hypothyroidism | en_US |
dc.title | Risk factors for gestational diabetes: An umbrella review of meta-analyses of observational studies | en_US |
dc.type | Article | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | University of Ioannina | en_US |
dc.collaboration | Imperial College London | en_US |
dc.collaboration | University of Cyprus | en_US |
dc.collaboration | Kentro Iatrikis Ioanninon | en_US |
dc.collaboration | Harvard University | en_US |
dc.subject.category | Clinical Medicine | en_US |
dc.journals | Open Access | en_US |
dc.country | Cyprus | en_US |
dc.country | Greece | en_US |
dc.country | United Kingdom | en_US |
dc.country | United States | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1371/journal.pone.0215372 | en_US |
dc.relation.issue | 4 | en_US |
dc.relation.volume | 14 | en_US |
cut.common.academicyear | 2018-2019 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.journal.journalissn | 1932-6203 | - |
crisitem.journal.publisher | PloS | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.dept | Department of Nursing | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0002-8339-9285 | - |
crisitem.author.orcid | 0000-0003-0503-1538 | - |
crisitem.author.orcid | 0000-0001-6358-8591 | - |
crisitem.author.orcid | 0000-0002-9451-9094 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Appears in Collections: | Άρθρα/Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
journal.pone.0215372.pdf | Fulltext | 762.53 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
5
81
checked on Nov 6, 2023
WEB OF SCIENCETM
Citations
75
Last Week
0
0
Last month
4
4
checked on Oct 29, 2023
Page view(s)
384
Last Week
1
1
Last month
2
2
checked on Jan 3, 2025
Download(s)
94
checked on Jan 3, 2025
Google ScholarTM
Check
Altmetric
Items in KTISIS are protected by copyright, with all rights reserved, unless otherwise indicated.