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https://hdl.handle.net/20.500.14279/1251
Title: | Neurodevelopmental Outcome of Fetuses with IncNreased Uchal Translucency and Apparently Normal Prenatal and/or Postnatal Assessment: a Systematic Review |
Authors: | Sotiriadis, Alexandros Papatheodorou, Stefania Makrydimas, George V. |
Major Field of Science: | Medical and Health Sciences |
Field Category: | Clinical Medicine |
Keywords: | Neurodevelopment;Nuchal translucency;Ultrasound |
Issue Date: | Jan-2012 |
Source: | Ultrasound in Obstetrics and Gynecology, 2012, vol.39, no.1, pp. 10–19 |
Volume: | 39 |
Issue: | 1 |
Start page: | 10 |
End page: | 19 |
Journal: | Ultrasound in Obstetrics and Gynecology |
Abstract: | Objectives: To systematically review and, when feasible, pool, published data regarding the prevalence of childhood neurodevelopmental delay in fetuses with increased first-trimester nuchal translucency (NT), normal karyotype and absence of structural defects or identifiable syndromes. Methods: MEDLINE and SCOPUS searches using combinations of the terms 'nuchal translucency' AND 'outcome*' were complemented by perusal of the references of the retrieved articles and an additional automated search using the 'search for related articles' PubMed function. Only children with a normal karyotype and no structural defects or syndromic abnormalities were included in the analysis. Between-studies heterogeneity was assessed using the I 2 statistic. Results: The total prevalence of developmental delay in all 17 studies was 28/2458 (1.14%; 95% CI, 0.79-1.64; I 2 = 57.6%). Eight studies (n = 1567) used NT > 99th centile as the cut-off; 15 children (0.96%; 95% CI, 0.58-1.58%) were reported as having developmental delay (I 2 = 72.2%). Four studies (n = 669) used the 95 th centile as the cut-off for increased NT; seven children (1.05%; 95% CI, 0.51-4.88%) were reported as having developmental delay (I 2 = 29.2%). Five studies used 3.0 mm as the cut-off for increased NT; the pooled rate of developmental delay was six of 222 children (2.70%; 95% CI, 1.24-5.77%; I 2 = 0.0%). Conclusion The rate of neurodevelopmental delay in children with increased fetal NT, a normal karyotype, normal anatomy and no identifiable genetic syndromes does not appear to be higher than that reported for the general population. More large-scale, prospective case-control studies would be needed to enhance the robustness of the results. |
URI: | https://hdl.handle.net/20.500.14279/1251 |
ISSN: | 14690705 |
DOI: | 10.1002/uog.1014 |
Rights: | @ 2011 ISUOG |
Type: | Article |
Affiliation : | Aristotle University of Thessaloniki University of Ioannina |
Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
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