Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/1236
Title: | Serum total homocysteine, folate, 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T genotype and subclinical atherosclerosis | Authors: | Panayiotou, Andrie G. Nicolaides, Andrew N. Griffin, Maura B. Tyllis, Theodosis K. Georgiou, Niki Martin, Richard M. Bond, Dawn Tziakouri-Shiakalli, Chrysa Fessas, Charis H. Constantinou-Deltas, Constantinos D. |
Major Field of Science: | Medical and Health Sciences | Field Category: | Clinical Medicine | Keywords: | Folate;Homocysteine;IMT;MTHFR;Subclinical atherosclerosis;Ultrasound | Issue Date: | Jan-2009 | Source: | Expert Opinion on Therapeutic Targets, 2009, vol. 13, no, 1, pp. 1-11 | Volume: | 13 | Issue: | 1 | Start page: | 1 | End page: | 11 | Journal: | Expert Opinion on Therapeutic Targets | Abstract: | Objective : To determine the relationship of serum total homocysteine (tHcy), serum folate and 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T genotype with ultrasonic arterial wall measurements associated with subclinical atherosclerosis. Study design : Cross-sectional analysis of 767 participants in an ongoing prospective study. Intima-media thickness (IMT) of the common carotid (IMTcc), IMT of the internal carotid including plaque when present (IMTmax) and the sum of the thickest plaques present in both carotid and both common femoral bifurcations (total plaque thickness (TPT)) were measured using ultrasound. Results : People in the upper homocysteine quartile were more likely to have clinical cardiovascular disease (CVD) than those in the lowest three quartiles. They were also more likely to have plaques. The MTHFR 677C→T genotype was not associated with any of the measures of subclinical atherosclerosis in either men or women but was the most important determinant of total homocysteine levels in men under 60 years of age. Conclusions : Increased homocysteine levels but not MTHFR 677C→T genotype, are associated with subclinical atherosclerosis and the presence of plaques. Our results indicate that measurements of blood levels of homocysteine and folate in people at intermediate risk for atherosclerotic CVD before symptoms occur, might improve risk stratification and facilitate the decision to provide folate/B vitamin intervention in primary prevention. | URI: | https://hdl.handle.net/20.500.14279/1236 | ISSN: | 17447631 | DOI: | 10.1517/14728220802560281 | Rights: | © Taylor & Francis | Type: | Article | Affiliation : | University of Cyprus Cyprus Cardiovascular Disease and Educational Research Trust Imperial College London Cyprus Institute of Neurology and Genetics Vascular Screening and Diagnostic Center University of Bristol Nicosia General Hospital Cyprus Heart Foundation |
Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
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