Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/1231
Title: | Carotid and femoral arterial wall changes and the prevalence of clinical cardiovascular disease | Authors: | Griffin, Maura B. Nicolaides, Andrew N. Tyllis, Theodosis H. Georgiou, Niki Martin, Richard Michael Bond, Dawn Panayiotou, Andrie G. Tziakouri, Chrysa Dore, Caroline J. Fessas, Charis C. |
Major Field of Science: | Medical and Health Sciences | Field Category: | Clinical Medicine | Keywords: | Arterial wall;Atherosclerosis;Ultrasonic imaging | Issue Date: | Aug-2009 | Source: | Vascular Medicine, 2009, vol. 14, no. 3, pp. 227-232 | Volume: | 14 | Issue: | 3 | Start page: | 227 | End page: | 232 | Journal: | Vascular Medicine | Abstract: | The Cyprus Study is a prospective cohort study of cardiovascular disease (CVD). Its aim is to determine the relationship of intima–media thickness (IMT) of the common carotid (IMTcc), maximum thickness of IMT in the carotid bifurcation (IMTmax), number of carotid and femoral bifurcations with plaque and total plaque thickness (TPT) (sum of the maximum plaque measurements taken from the four bifurcations scanned) with the prevalence of clinical CVD. A total of 767 individuals (46% male) over the age of 40 years were recruited from a mountain village and a town outside the capital Nicosia. In addition to clinical examination, carotid and common femoral bifurcations were scanned with ultrasound. After controlling for conventional risk factors, there was little evidence of an association of IMTcc with CVD prevalence. However, IMTmax and TPT were associated with 2.9-fold (1.22 to 7.07) and 6.87-fold (2.42 to 19.43) increased odds of CVD prevalence, respectively. In conclusion, the TPT and number of bifurcations with plaque are more strongly associated with the prevalence of CVD. These findings warrant investigation in prospective studies to document associations with incident CVD events. | URI: | https://hdl.handle.net/20.500.14279/1231 | ISSN: | 14770377 | DOI: | 10.1177/1358863X08101542 | Rights: | © Sage | Type: | Article | Affiliation : | Vascular Screening and Diagnostic Center Cyprus Institute of Neurology and Genetics University of Cyprus Imperial College London University of Bristol Nicosia General Hospital MRC Clinical Trials Unit Cyprus Heart Foundation |
Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
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