Association of proinflammatory molecules with apoptotic markers and survival in critically ill multiple organ dysfunction patients
Journal
Biological Research for Nursing
Date Issued
October 1, 2003
DOI
10.1177/1099800403257189
Abstract
Recent evidence supports the involvement of
apoptosis in multiple organ dysfunction (MODS). The
authors examined the hypothesis that nitric oxide (NO),
interleukin (IL)-6, tumor necrosis factor (TNF)-α, and
cortisol correlate with Fas and Fas ligand (FasL)
expression on peripheral blood mononuclear cells and
that Fas and FasL, therefore, mediate their association
with MODS severity. Thirty-five critically ill adult
MODS patients were followed for up to 14 days and
were compared to non-MODS matched controls. Fas,
FasL, nitrate, cortisol, and IL-6 were elevated in
MODS patients (P < 0.05). Nitrate and cortisol correlated
with Fas expression (P < 0.05). All factors studied,
except for TNF-α, correlated with MODS severity
(P< 0.05); however, by multivariate analyses, Fas and
FasL were independently associated with severity and
survival (P < 0.05). The inflammatory molecules studied
may mediate the association of apoptotic constituents
with MODS severity and survival only in part.
apoptosis in multiple organ dysfunction (MODS). The
authors examined the hypothesis that nitric oxide (NO),
interleukin (IL)-6, tumor necrosis factor (TNF)-α, and
cortisol correlate with Fas and Fas ligand (FasL)
expression on peripheral blood mononuclear cells and
that Fas and FasL, therefore, mediate their association
with MODS severity. Thirty-five critically ill adult
MODS patients were followed for up to 14 days and
were compared to non-MODS matched controls. Fas,
FasL, nitrate, cortisol, and IL-6 were elevated in
MODS patients (P < 0.05). Nitrate and cortisol correlated
with Fas expression (P < 0.05). All factors studied,
except for TNF-α, correlated with MODS severity
(P< 0.05); however, by multivariate analyses, Fas and
FasL were independently associated with severity and
survival (P < 0.05). The inflammatory molecules studied
may mediate the association of apoptotic constituents
with MODS severity and survival only in part.