Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/1173
Title: Serum leptin levels are higher but are not independentlyassociated with severity or mortality in the multipleorgan dysfunction/systemic inflammatory responsesyndrome: a matched case control and a longitudinalstudy
Authors: Papathanassoglou, Elizabeth 
Moynihan, Jan 
Ackerman, Michael John 
Mantzoros, Christos S. 
Major Field of Science: Medical and Health Sciences
Field Category: Health Sciences
Keywords: Hypercatabolism;Immune dysfunction;Leptin;Tumor necrosis factor alpha
Issue Date: Feb-2001
Source: Clinical Endocrinology, 2001, vol. 54, no. 2, pp. 137–281
Volume: 54
Issue: 2
Start page: 137
End page: 281
Journal: Clinical Endocrinology 
Abstract: OBJECTIVE Hypercatabolism and immune dysfunc-tion are closely associated with the development ofsystemic inflammatory response±multiple organdysfunction (SIRS/MODS) in critical illness. It remainsunclear however, whether leptin, an adipocyte-derived hormone whose levels are influenced byseveral cytokines and which regulates immune func-tion, food-intake and energy expenditure is indepen-dently related to the development of and/or severityand mortality from SIRS/MODS.DESIGN and PATIENTS To assess the role of leptin inSIRS/MODS we performed a matched case controland a longitudinal study (14 days) in 35 critically illpatients with SIRS/MODS and 35 matched controls.RESULTS Baseline leptin levels were positivelyassociated with body mass index (BMI) and TNF-a(P , 0´01) in patients and with IGF-1 and IL-6 levels(P , 0´05) in controls. Furthermore, leptin levelsexhibited a progressive increase from the first tothe last day of the study and although baseline levels were not different, peak leptin levels as well as leptinlevels on the last day of the study were significantlyhigher in cases than in controls (P , 0´05). TNF-alevels, IL-6 and cortisol levels were also higher,whereas IGF-1 levels were lower in cases (P , 0´05).To assess whether leptin levels are independentlyassociated with SIRS/MODS we performed multi-variate logistic regression analysis which revealedthat leptin up-regulation in cases is mediated byelevated TNF-a and cortisol levels. Finally, there wasno independent association between leptin andsurvival in this group of critically ill patients.CONCLUSION We conclude that cytokines and corti-sol upregulate leptin levels, which may contributeto the development of the hypercatabolism, wastingand immune dysfunction but leptin levels are notindependently associated with severity or mortalityof patients with systemic inflammatory response±multiple organ dysfunction.
URI: https://hdl.handle.net/20.500.14279/1173
ISSN: 13652265
DOI: 10.1046/j.1365-2265.2001.01209.x
Rights: © John Wiley & Sons Ltd
Type: Article
Affiliation : Harvard University 
University of Rochester 
Appears in Collections:Άρθρα/Articles

CORE Recommender
Show full item record

SCOPUSTM   
Citations

44
checked on Nov 9, 2023

WEB OF SCIENCETM
Citations

36
Last Week
0
Last month
0
checked on Oct 26, 2023

Page view(s)

527
Last Week
0
Last month
13
checked on May 19, 2024

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons