Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/11704
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Charisiadis, Pantelis | - |
dc.contributor.author | Andrianou, Xanthi | - |
dc.contributor.author | Van Der Meer, Thomas P. | - |
dc.contributor.author | Den Dunnen, Wilfred F. A. | - |
dc.contributor.author | Swaab, Dick F. | - |
dc.contributor.author | Wolffenbuttel, Bruce H. R. | - |
dc.contributor.author | Makris, Konstantinos C. | - |
dc.contributor.author | Van Vliet-Ostaptchouk, Jana V. | - |
dc.date.accessioned | 2018-06-28T12:12:15Z | - |
dc.date.available | 2018-06-28T12:12:15Z | - |
dc.date.issued | 2018-12-01 | - |
dc.identifier.citation | Scientific Reports, 2018, vol. 8, no. 1 | en_US |
dc.identifier.issn | 29844501 | - |
dc.description.abstract | Evidence of bisphenols’ obesogenic efects on humans is mixed and inconsistent. We aimed to explore the presence of bisphenol A (BPA), bisphenol F (BPF) and chlorinated BPA (ClBPA), collectively called the bisphenols, in diferent brain regions and their association with obesity using post-mortem hypothalamic and white matter brain material from twelve pairs of obese (body mass index (BMI) >30kg/m2) and normal-weight individuals (BMI <25kg/m2). Mean ratios of hypothalamus:white matter for BPA, BPF and ClBPA were 1.5, 0.92, 0.95, respectively, suggesting no preferential accumulation of the bisphenols in the grey matter (hypothalamic) or white matter-enriched brain areas. We observed diferences in hypothalamic concentrations among the bisphenols, with highest median level detected for ClBPA (median: 2.4ng/g), followed by BPF (2.2ng/g) and BPA (1.2ng/g); similar ranking was observed for the white matter samples (median for: ClBPA-2.5ng/g, BPF-2.3ng/g, and BPA1.0ng/g). Furthermore, all bisphenol concentrations, except for white-matter BPF were associated with obesity (p<0.05). This is the frst study reporting the presence of bisphenols in two distinct regions of the human brain. Bisphenols accumulation in the white matter-enriched brain tissue could signify that they are able to cross the blood-brain barrier. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.rights | © The Author(s) | en_US |
dc.subject | Bisphenol A | en_US |
dc.subject | Bisphenol F | en_US |
dc.subject | Chlorinated BPA | en_US |
dc.subject | Bisphenols | en_US |
dc.title | Possible obesogenic effects of bisphenols accumulation in the human brain | en_US |
dc.type | Article | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | University of Groningen | en_US |
dc.collaboration | Royal Netherlands Academy of Arts and Sciences | en_US |
dc.subject.category | Basic Medicine | en_US |
dc.journals | Open Access | en_US |
dc.country | Cyprus | en_US |
dc.country | Netherlands | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1038/s41598-018-26498-y | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.volume | 8 | en_US |
cut.common.academicyear | 2017-2018 | en_US |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
crisitem.journal.journalissn | 2045-2322 | - |
crisitem.journal.publisher | Springer Nature | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0001-7260-192X | - |
crisitem.author.orcid | 0000-0002-2906-5743 | - |
crisitem.author.orcid | 0000-0001-5251-8619 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Appears in Collections: | Άρθρα/Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s41598-018-26498-y.pdf | Fulltext | 1.17 MB | Adobe PDF | View/Open |
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