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dc.contributor.authorKaliviotis, Efstathios-
dc.contributor.authorSherwood, Joseph M.-
dc.contributor.authorBalabani, Stavroula-
dc.date.accessioned2018-04-19T08:26:49Z-
dc.date.available2018-04-19T08:26:49Z-
dc.date.issued2018-03-01-
dc.identifier.citationPhysics of Fluids, 2018, vol. 30, no. 3en_US
dc.identifier.issn10706631-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/10950-
dc.description.abstractThe red blood cell (RBC) aggregation phenomenon is majorly responsible for the non-Newtonian nature of blood, influencing the blood flow characteristics in the microvasculature. Of considerable interest is the behaviour of the fluid at the bifurcating regions. In vitro experiments, using microchannels, have shown that RBC aggregation, at certain flow conditions, affects the bluntness and skewness of the velocity profile, the local RBC concentration, and the cell-depleted layer at the channel walls. In addition, the developed RBC aggregates appear unevenly distributed in the outlets of these channels depending on their spatial distribution in the feeding branch, and on the flow conditions in the outlet branches. In the present work, constitutive equations of blood viscosity, from earlier work of the authors, are applied to flows in a T-type bifurcating microchannel to examine the local viscosity characteristics. Viscosity maps are derived for various flow distributions in the outlet branches of the channel, and the location of maximum viscosity magnitude is obtained. The viscosity does not appear significantly elevated in the branches of lower flow rate as would be expected on the basis of the low shear therein, and the maximum magnitude appears in the vicinity of the junction, and towards the side of the outlet branch with the higher flow rate. The study demonstrates that in the branches of lower flow rate, the local viscosity is also low, helping us to explain why the effects of physiological red blood cell aggregation have no adverse effects in terms of in vivo vascular resistance.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofPhysics of Fluidsen_US
dc.rights© Author(s)en_US
dc.subjectBifurcation (mathematics)en_US
dc.subjectBlooden_US
dc.subjectBlood pressureen_US
dc.subjectCellsen_US
dc.subjectConstitutive equationsen_US
dc.subjectHemodynamicsen_US
dc.subjectMicrochannelsen_US
dc.subjectMicrofluidicsen_US
dc.titleLocal viscosity distribution in bifurcating microfluidic blood flowsen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationUniversity College Londonen_US
dc.collaborationImperial College Londonen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.countryUnited Kingdomen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1063/1.5011373en_US
dc.relation.issue3en_US
dc.relation.volume30en_US
cut.common.academicyear2017-2018en_US
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
item.grantfulltextopen-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.journal.journalissn1089-7666-
crisitem.journal.publisherAmerican Institute of Physics-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.orcid0000-0003-4149-4396-
crisitem.author.parentorgFaculty of Engineering and Technology-
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