The aftereffects of a gamma frequency stimulation in motor cortex: A Case

Abstract

Transcranial magnetic stimulation (TMS) is a noninvasive technique that is used to modulating brain activity. TMS can be used not only for patients but also for healthy individuals. Gamma oscillations at 40 Hz have been shown to cause an overall neuroprotective response that recruits both neurons and microglia on a mouse model. 40 Hz frequency has been confirmed to be able to drastically improve mental function as they have also drastically reduced AD symptoms. Objective: To assess the safety and aftereffects of 40 Hz TMS stimulation on motor cortex in a healthy subject. Methods: A case study, one subject received one session of 40 Hz TMS over the motor cortex. The applied protocol involved 25 trains of 40 Hz TMS with 29sec interval rest at 80% of subject’s resting motor threshold (RMT). The experiment lasted almost 12 min. Motor threshold re-tested after 5, 10 and 15 minutes. Results: There were no side effects of 40 Hz rTMS apart from transient headache. There was no significant change in the RMT after rTMS. Conclusions: This study could be a first step in exploring the impact of therapeutic potential.