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Τίτλος: Optimization of a horizontal slot waveguide biosensor to detect DNA hybridization
Συγγραφείς: Viphavakit, Charusluk 
Komodromos, Michael 
Themistos, Christos 
Mohammed, Waleed S. 
Kalli, Kyriacos 
Rahman, B. M. Azizur 
Major Field of Science: Engineering and Technology
Field Category: Electrical Engineering - Electronic Engineering - Information Engineering
Λέξεις-κλειδιά: DNA;DNA, Single-Stranded;Equipment design;Models theoretical;Oxides;Oxygen;Refractometry;Reproducibility of results;Silicon;Silicon dioxide;Biosensing techniques;Nucleic Acid Hybridization
Ημερομηνία Έκδοσης: 20-Μαΐ-2015
Πηγή: Applied Optics, 2015, vol. 54, no. 15, pp. 4881-4888.
Volume: 54
Issue: 15
Start page: 4881
End page: 4888
DOI: 10.1364/AO.54.004881
Περιοδικό: Applied Optics 
Περίληψη: A full-vectorial H-field formulation-based finite element approach is used to optimize a biosensor structure incorporating a horizontal slot waveguide. It is designed to detect DNA hybridization through the change of the effective index of the waveguide structure. The key parameters, such as normalized power confinement, power density, change in effective index, and sensitivity are presented by optimizing the device parameters of the slot waveguide. It is shown here that a 90.0 μm long compact Mach-Zehnder section can be designed with horizontal slot waveguide to detect DNA hybridization and for a ring resonator arrangement a sensitivity of 893.5 nm/RIU is obtained.
URI: https://hdl.handle.net/20.500.14279/9518
ISSN: 1559128X
DOI: 10.1364/AO.54.004881
Rights: © Optical Society of America.
Type: Article
Affiliation: Frederick University 
Bangkok University 
Cyprus University of Technology 
City, University of London 
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