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https://hdl.handle.net/20.500.14279/22747
Τίτλος: | Focused ultrasound phantom model for blood brain barrier disruption | Συγγραφείς: | Alekou, Tereza Giannakou, Marinos Damianou, Christakis A. |
Major Field of Science: | Medical and Health Sciences | Field Category: | Clinical Medicine | Λέξεις-κλειδιά: | BBB;FUS;Phantom;Ultrasound | Ημερομηνία Έκδοσης: | Φεβ-2021 | Πηγή: | Ultrasonics, 2021, vol. 110, articl. no. 106244 | Volume: | 110 | Περιοδικό: | Ultrasonics | Περίληψη: | In this paper a high intensity focused ultrasound (FUS) phantom model was developed, in order to be used in experiments for Blood Brain Barrier (BBB) disruption. The target was to create a phantom model that represents the disruption of the BBB during ultrasound application. An appropriate experimental setup was created bearing a single element transducer with diameter 50 mm and geometric focus 100 mm operating at 0.5 MHz. It included a set of tubes and a connector with multiple 0.4 mm openings, through which a suitable liquid is being circulated with a pump. The lesions were sealed with a thin homogenous layer of wax, preventing a liquid leakage. The system was tested successfully with FUS and a liquid leakage was achieved after FUS application. This set up is the first phantom model that has the potential to be utilized as a cost-effective solution for performing experiments for BBB disruption, without the need of using animal models. | URI: | https://hdl.handle.net/20.500.14279/22747 | ISSN: | 0041624X | DOI: | 10.1016/j.ultras.2020.106244 | Rights: | © Elsevier Attribution-NonCommercial-NoDerivatives 4.0 International |
Type: | Article | Affiliation: | Cyprus University of Technology |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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