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|Title:||Impact of head rotation on the individualized common carotid flow and carotid bifurcation hemodynamics||Authors:||Aristokleous, Nicolas
Georgiou, Georgios C.
Brott, Brigitta C.
Nicolaides, Andrew N.
|Keywords:||Atherosclerosis;Carotid artery bifurcation;Imaged-based computational fluid dynamics (CFD);Wall shear stress||Category:||Materials Engineering||Field:||Engineering and Technology||Issue Date:||1-Jan-2014||Publisher:||Institute of Electrical and Electronics Engineers Inc.||Source:||IEEE Journal of Biomedical and Health Informatics Volume 18, Issue 3, May 2014, Article number 6746053, Pages 783-789||DOI:||10.1109/JBHI.2014.2305575||Abstract:||This paper aims at evaluating the changes that head rotation poses on morphological and flow characteristics of the carotid bifurcation (CB) and on the distribution of parameters that are regarded as important in atherosclerosis development, such as relative particle residence time (RRT), normalized oscillatory shear index (nOSI), and helicity (HL). Using a subject-specific approach, six healthy volunteers were MR-scanned in two head postures: supine neutral and prone with rightward head rotation. Cross-sectional flow velocity distribution was obtained using phase-contrast MRI at the common carotid artery (CCA). Our results indicate that peak systolic flow rate is reduced at the prone position in most cases for both CCAs. Morphological MR images are used to segment and construct the CB models. Numerical simulations are performed and areas exposed to high helicity or unfavorable hemodynamics are calculated. Head rotation affects the instantaneous spatial extent of high helicity regions. Posture-related observed differences in the distribution of nOSI and RRT suggest that inlet flow waveform tends to moderate geometry-induced changes in the qualitative and quantitative distribution of atherosclerosis-susceptible wall regions. Overall, presented results indicate that an individualized approach is required to fully assess the postural role in atherosclerosis development and in complications arising in stenotic and stented vessels.||URI:||http://ktisis.cut.ac.cy/handle/10488/9918||ISSN:||21682194||Rights:||© 2013 IEEE.||Type:||Article|
|Appears in Collections:||Άρθρα/Articles|
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