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dc.contributor.authorLiu, Xiaowen-
dc.contributor.authorHamnvik, Ole Petter Riksfjord-
dc.contributor.authorChamberland, John P.-
dc.contributor.authorPetrou, Michael-
dc.contributor.authorGong, Huizhi-
dc.contributor.authorChristophi, Costas A.-
dc.contributor.authorChristiani, David C.-
dc.contributor.authorKales, Stefanos N.-
dc.contributor.authorMantzoros, Christos S.-
dc.contributor.otherΠέτρου, Μιχαήλ-
dc.contributor.otherΧριστοφή, Κώστας-
dc.identifier.citationMetabolism: Clinical and Experimental Volume 63, Issue 6, June 2014, Pages 773-782en_US
dc.description.abstractObjective To comparatively evaluate traditional liver tests and fetuin A as predictors of cardiometabolic risk, we studied associations between serum alanine transaminase (ALT), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST) and fetuin-A and anthropometric, metabolic, and cardiovascular parameters cross-sectionally at baseline, and prospectively, after 2-years of follow-up. Research Design and Methods 616 randomly enrolled young healthy participants in the Cyprus Metabolism Study, including all 93 subjects who participated in the follow-up study 2 years after baseline assessment, were included in this study. Results In the cross-sectional study, serum ALT and GGT were strongly correlated with anthropometric, cardiovascular, and metabolic variables, while serum AST was only correlated with waist circumference and waist-to-hip ratio. Fetuin-A was correlated with anthropometric variables, systolic blood pressure (SBP), insulin, and homeostasis model of assessment-insulin resistance (HOMA-IR) in the unadjusted model. In the fully adjusted model, both serum ALT and GGT levels remained positively correlated with total and low-density lipoprotein (LDL) cholesterol. GGT levels also remained correlated with triglycerides. ALT levels remained strongly positively correlated with insulin (r = 0.17, p <.0001) and HOMA-IR (r = 0.16, p = 0.0001). Serum fetuin-A levels were no longer significantly correlated with any variables. Prospectively, ALT and GGT were predictors of anthropometric variables and LDL cholesterol, while baseline levels of AST and fetuin-A were not predictors of any variables at 2-year follow-up. Conclusions We confirmed associations of ALT and GGT levels but failed to demonstrate an independent association between fetuin-A and cardiometabolic risk factors in young healthy men. Traditional liver tests (LFTs) are thus better than fetuin-A predictors of metabolic risk factors cross-sectionally and prospectively in young healthy adults.en_US
dc.publisherW.B. Saundersen_US
dc.rights© 2014 Elsevier B.V. All rights reserved.en_US
dc.subjectInsulin resistanceen_US
dc.subjectMetabolic syndromeen_US
dc.titleCirculating alanine transaminase (ALT) and γ-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: The prospective Cyprus Metabolism Studyen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationHarvard Medical Schoolen_US
dc.collaborationHarvard School of Public Healthen_US
dc.collaborationBoston VA Healthcare Systemen_US
dc.subject.categoryBasic Medicineen_US
dc.journalsSubscription Journalen_US
dc.countryUnited Statesen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
item.fulltextNo Fulltext-
item.grantfulltextnone- International Institute for Environmental and Public Health- of Health Sciences- of Health Sciences-
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