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dc.contributor.authorVamvini, Maria T.-
dc.contributor.authorAronis, Konstantinos N.-
dc.contributor.authorPanagiotou, Grigorios-
dc.contributor.authorHuh, Jooyoung-
dc.contributor.authorChamberland, John P.-
dc.contributor.authorBrinkoetter, Mary T.-
dc.contributor.authorPetrou, Michael A.-
dc.contributor.authorChristophi, Costas A.-
dc.contributor.authorKales, Stefanos N.-
dc.contributor.authorChristiani, David C.-
dc.contributor.authorMantzoros, Christos S.-
dc.contributor.otherΠέτρου, Μιχάλης Α.-
dc.contributor.otherΧριστοφή, Κώστας-
dc.identifier.citationEuropean Journal of Endocrinology, 2013, Volume 169, Issue 6, Pages 829-834en_US
dc.description.abstractObjective: Skeletal muscle is considered to be an endocrine organ that secretes a number of myokines including follistatin (FST), myostatin (MSTN), activin A, and the newly identified irisin. Irisin's biology and function exhibit similarities with the functions of the FST-MSTN-activin A axis. It remains unknown whether there is any interplay among these molecules. The aim of this study is to examine potential associations of irisin with the FST, MSTN, and activin A axis. Methods: Two observational studies were performed to evaluate the associations of irisin with the other three peptides. Study A included 150 healthy males aged 18.48G0.16 years with BMI 23.18±3.75 kg/m2. Fasting serum samples were used to measure the levels of the molecules of interest. Study B included 14 morbidly obese individuals, candidates for bariatric surgery, aged 53.14±8.93 years with BMI 50.18±10.63 kg/m2. Blood samples were obtained after an overnight fast. Eight out of the 14 participants consented to an optional thigh biopsy during their bariatric surgery. Using the above blood and tissue samples, we measured circulating levels and muscle mRNA of irisin, FST, MSTN, and activin A. Results: We report that FNDC5 mRNA in muscle is positively correlated with FST mRNA expression in morbidly obese subjects (ρ=0.93, P<0.001). We also found that circulating irisin is positively correlated with FST circulating levels among lean subjects (ρ=0.17, P=0.05) while this association was suggestive among the obese (ρ=0.56, P=0.07). Conclusion: The newly identified myokine irisin may be positively associated with FST at both the mRNA and circulating protein level.en_US
dc.publisherEuropean Society of Endocrinologyen_US
dc.rights© 2013 European Society of Endocrinologyen_US
dc.subjectSkeletal muscleen_US
dc.subjectMyostatin (MSTN)en_US
dc.titleIrisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humansen_US
dc.collaborationHarvard Medical Schoolen_US
dc.collaborationJohns Hopkins Hospitalen_US
dc.collaborationChonnam National Universityen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationHarvard School of Public Healthen_US
dc.collaborationBeth Israel Deaconess Medical Centeren_US
dc.subject.categoryHealth Sciencesen_US
dc.journalsSubscription Journalen_US
dc.countryUnited Statesen_US
dc.countrySouth Koreaen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
item.fulltextNo Fulltext-
item.grantfulltextnone- International Institute for Environmental and Public Health- of Health Sciences- of Health Sciences-
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