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Title: Surface modified nitinol stents release metal ions in blood
Authors: Kapnisis, Konstantinos 
Eleftheriou, Polyvios 
Lapathitis, George 
Karaiskos, Christos 
Beck, Preston 
Lemons, Jack 
Connolly, David 
Pitsillides, Costas 
Anayiotos, Andreas 
Major Field of Science: Engineering and Technology
Field Category: Materials Engineering
Keywords: Ions;Metals;Blood;Nickel titanium alloys;Stents
Issue Date: 1-Jun-2013
Source: ASME 2013 Summer Bioengineering Conference, SBC 2013; Sunriver, OR; United States; 26 June 2013 through 29 June 2013
DOI: 10.1115/SBC2013-14244
Abstract: Intravascular nitinol stents are used in the treatment of atherosclerosis and intracranial aneurysms. Despite the unique physical properties of shape memory and superelasticity, the chemical composition of NiTi has raised concerns due to the presence of nickel ions within the alloy which can have adverse effects on human health. Currently, stents are manufactured from corrosion resistant alloys which form protective titanium oxide films, insulating the bulk material from the corrosive physiologic fluid. However, nanometer thick regions of oxides are lost at locations of high strain due to significant bending, micromotion between overlapping stents or local calcification1‐2. Recent studies have revealed that some stents undergo corrosion in vivo, with significant release of metallic ions into surrounding tissues3–4. In this project, a range of techniques has been employed to modify the surface of miniature NiTi stents in order to mimic in vivo corrosion and correlate the amount of nickel ions released with the findings in explanted tissue.
ISBN: 978-079185560-7
Rights: © 2013 ASME
Type: Conference Papers
Affiliation : Cyprus University of Technology 
Cyprus Institute of Neurology and Genetics 
University of Alabama at Birmingham 
International Research and Development Centre 
Appears in Collections:Δημοσιεύσεις σε συνέδρια /Conference papers or poster or presentation

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