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Title: MRI-compatible positioning device for guiding a focused ultrasound system for transrectal treatment of prostate cancer
Authors: Yiallouras, Christos 
Mylonas, Nicos 
Damianou, Christakis A. 
Major Field of Science: Medical and Health Sciences
Field Category: Medical Engineering
Keywords: MRI;Prostate;Ultrasound
Issue Date: 1-Jul-2014
Source: International Journal of Computer Assisted Radiology and Surgery, 2014, vol. 9, no. 4, pp. 745-753
Volume: 9
Issue: 4
Start page: 745
End page: 753
Journal: International Journal of Computer Assisted Radiology and Surgery 
Abstract: Background   : High-intensity focused ultrasound (HIFU) is a promising treatment method for many common cancers, including prostate cancer. Magnetic resonance image (MRI) guidance of HIFU permits targeting and monitoring of therapy. A prototype MRI-compatible positioning device that navigates a HIFU transducer was designed, fabricated and tested. Materials and methods   : The positioning device has two PC-controlled and one manually driven stage that allow endorectal access to the prostate. The positioning device was constructed using a 3-D rapid prototype manufacturing device. Software was developed that controls the motion of the positioning device and enables activation of a HIFU transducer. In vitro testing of the system was performed in a 1.5T MRI scanner using ex vivo turkey tissue. Optical encoders were employed to enhance the accuracy of this positioning device. Result   : The positioning device was successfully tested for MRI compatibility. The movement error of the positioning device is approximately 20 μm. The robot has the ability to accurately move the transducer for creation of discrete and overlapping lesions. Conclusion   : An MRI-compatible HIFU positioning system was developed that has the ability to create thermal lesions with MRI guidance for endorectal treatment of prostate cancer.
ISSN: 1861-6410
DOI: 10.1007/s11548-013-0964-x
Rights: © Springer Nature
Type: Article
Affiliation : Cyprus University of Technology 
Frederick Research Center 
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