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Title: Optimization of a horizontal slot waveguide biosensor to detect DNA hybridization
Authors: Viphavakit, Charusluk 
Komodromos, Michael 
Themistos, Christos 
Mohammed, Waleed S. 
Kalli, Kyriacos 
Rahman, B. M. Azizur 
Keywords: DNA;DNA, Single-Stranded;Equipment design;Models theoretical;Oxides;Oxygen;Refractometry;Reproducibility of results;Silicon;Silicon dioxide;Biosensing techniques;Nucleic Acid Hybridization
Category: Electrical Engineering - Electronic Engineering - Information Engineering
Field: Engineering and Technology
Issue Date: 20-May-2015
Publisher: OSA - The Optical Society
Source: Applied Optics, 2015, vol. 54, no. 15, pp. 4881-4888
DOI: 10.1364/AO.54.004881
Journal: Applied Optics 
Abstract: A full-vectorial H-field formulation-based finite element approach is used to optimize a biosensor structure incorporating a horizontal slot waveguide. It is designed to detect DNA hybridization through the change of the effective index of the waveguide structure. The key parameters, such as normalized power confinement, power density, change in effective index, and sensitivity are presented by optimizing the device parameters of the slot waveguide. It is shown here that a 90.0 μm long compact Mach-Zehnder section can be designed with horizontal slot waveguide to detect DNA hybridization and for a ring resonator arrangement a sensitivity of 893.5 nm/RIU is obtained.
ISSN: 1559-128X
DOI: 10.1364/AO.54.004881
Rights: © 2015 Optical Society of America.
Type: Article
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